Silymarin Constituents Enhance ABCA1 Expression in THP-1 Macrophages
AbstractSilymarin is a hepatoprotective mixture of flavonolignans and flavonoids extracted from the seeds of milk thistle (Silybum marianum L. Gaertn). This study investigates the effect of major bioactive constituents from silymarin, silybin A, silybin B, isosilybin A, isosilybin B, silydianin, silychristin, isosilychristin, and taxifolin, on the expression of ABCA1, an important cholesterol efflux transporter, in THP-1-derived macrophages. Four of the studied compounds, isosilybin A, silybin B, silychristin and isosilychristin, were found to significantly induce ABCA1 protein expression without affecting cell viability. Moreover, isosilybin A, a partial PPARγ agonist, was found to promote cholesterol efflux from THP-1 macrophages in a concentration-dependent manner. These findings first show ABCA1 protein up-regulating activity of active constituents of silymarin and provide new avenues for their further study in the context of cardiovascular disease. View Full-Text
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Wang, L.; Rotter, S.; Ladurner, A.; Heiss, E.H.; Oberlies, N.H.; Dirsch, V.M.; Atanasov, A.G. Silymarin Constituents Enhance ABCA1 Expression in THP-1 Macrophages. Molecules 2016, 21, 55.
Wang L, Rotter S, Ladurner A, Heiss EH, Oberlies NH, Dirsch VM, Atanasov AG. Silymarin Constituents Enhance ABCA1 Expression in THP-1 Macrophages. Molecules. 2016; 21(1):55.Chicago/Turabian Style
Wang, Limei; Rotter, Susanne; Ladurner, Angela; Heiss, Elke H.; Oberlies, Nicholas H.; Dirsch, Verena M.; Atanasov, Atanas G. 2016. "Silymarin Constituents Enhance ABCA1 Expression in THP-1 Macrophages." Molecules 21, no. 1: 55.
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