Next Article in Journal
An Expedient Regio- and Diastereoselective Synthesis of Hybrid Frameworks with Embedded Spiro[9,10]dihydroanthracene [9,3′]-pyrrolidine and Spiro[oxindole-3,2′-pyrrolidine] Motifs via an Ionic Liquid-Mediated Multicomponent Reaction
Next Article in Special Issue
Structure and Antibacterial Activity of Ambobactin, a New Telomycin-Like Cyclic Depsipeptide Antibiotic Produced by Streptomyces ambofaciens F3
Previous Article in Journal
Enantioselective Cycloaddition Reactions Catalyzed by BINOL-Derived Phosphoric Acids and N-Triflyl Phosphoramides: Recent Advances
Previous Article in Special Issue
Comparing the Antibacterial and Functional Properties of Cameroonian and Manuka Honeys for Potential Wound Healing—Have We Come Full Cycle in Dealing with Antibiotic Resistance?
Article Menu

Export Article

Open AccessReview
Molecules 2015, 20(9), 16127-16141; doi:10.3390/molecules200916127

Review of Platensimycin and Platencin: Inhibitors of β-Ketoacyl-acyl Carrier Protein (ACP) Synthase III (FabH)

Key Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou 730050, China
Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730000, China
Author to whom correspondence should be addressed.
Academic Editor: Peter J. Rutledge
Received: 9 July 2015 / Revised: 24 August 2015 / Accepted: 28 August 2015 / Published: 3 September 2015
View Full-Text   |   Download PDF [1964 KB, uploaded 3 September 2015]   |  


Platensimycin and platencin were successively discovered from the strain Streptomyces platensis through systematic screening. These natural products have been defined as promising agents for fighting multidrug resistance in bacteria by targeting type II fatty acid synthesis with slightly different mechanisms. Bioactivity studies have shown that platensimycin and platencin offer great potential to inhibit many resistant bacteria with no cross-resistance or toxicity observed in vivo. This review summarizes the general information on platensimycin and platencin, including antibacterial and self-resistant mechanisms. Furthermore, the total synthesis pathways of platensimycin and platencin and their analogues from recent studies are presented. View Full-Text
Keywords: platensimycin; platencin; drug resistance; antibacterial activities; synthesis; analogues platensimycin; platencin; drug resistance; antibacterial activities; synthesis; analogues

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Shang, R.; Liang, J.; Yi, Y.; Liu, Y.; Wang, J. Review of Platensimycin and Platencin: Inhibitors of β-Ketoacyl-acyl Carrier Protein (ACP) Synthase III (FabH). Molecules 2015, 20, 16127-16141.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top