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Molecules 2015, 20(9), 16278-16289; doi:10.3390/molecules200916278

Structure and Antibacterial Activity of Ambobactin, a New Telomycin-Like Cyclic Depsipeptide Antibiotic Produced by Streptomyces ambofaciens F3

College of Plant Protection, Northwest A & F University, Yangling 712100, Shanxi, China
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Author to whom correspondence should be addressed.
Academic Editor: Peter J. Rutledge
Received: 8 July 2015 / Revised: 31 August 2015 / Accepted: 2 September 2015 / Published: 9 September 2015
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Abstract

A new telomycin-like cyclic depsipeptide, ambobactin (1), was isolated from the metabolites of Streptomyces ambofaciens F3, an endophyte of Platycladus orientalis. Its structure was elucidated on the basis of extensive spectroscopic analysis and advanced Marfey’s method. Ambobactin is structurally related with telomycin, except that the configuration of the 3-methyltryptophanes in their structures is different. It exhibited strong antibacterial activity against both Gram-positive and Gram-negative bacteria. Furthermore, this investigation revealed that S. ambofaciens F3 is a new producer of telomycin-like antibiotics. View Full-Text
Keywords: cyclic depsipeptide; telomycin-like; Streptomyces ambofaciens F3; antibacterial activity cyclic depsipeptide; telomycin-like; Streptomyces ambofaciens F3; antibacterial activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Wei, S.; Zhang, W.; Ji, Z. Structure and Antibacterial Activity of Ambobactin, a New Telomycin-Like Cyclic Depsipeptide Antibiotic Produced by Streptomyces ambofaciens F3. Molecules 2015, 20, 16278-16289.

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