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Molecules 2015, 20(9), 15572-15588; doi:10.3390/molecules200915572

Studies on Cytotoxic Activity against HepG-2 Cells of Naphthoquinones from Green Walnut Husks of Juglans mandshurica Maxim

1
College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, China
2
College of Adult Education, Heilongjiang University of Chinese Medicine, Harbin 150040, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Isabel C. F. R. Ferreira
Received: 20 July 2015 / Revised: 16 August 2015 / Accepted: 19 August 2015 / Published: 26 August 2015
(This article belongs to the Collection Bioactive Compounds)
View Full-Text   |   Download PDF [890 KB, uploaded 26 August 2015]   |  

Abstract

Twenty-seven naphthoquinones and their derivatives, including four new naphthalenyl glucosides and twenty-three known compounds, were isolated from green walnut husks, which came from Juglans mandshurica Maxim. The structures of four new naphthalenyl glucosides were elucidated based on extensive spectroscopic analyses. All of these compounds were evaluated for their cytotoxic activities against the growth of human cancer cells lines HepG-2 by MTT [3-(4,5-dimethylthiazo l-2-yl)-2,5 diphenyl tetrazolium bromide] assay. The results were shown that most naphthoquinones in an aglycone form exhibited better cytotoxicity in vitro than naphthalenyl glucosides with IC50 values in the range of 7.33–88.23 μM. Meanwhile, preliminary structure-activity relationships for these compounds were discussed. View Full-Text
Keywords: Juglans mandshurica Maxim; green walnut husks; naphthoquinones; cytotoxic activity; structure-activity relationships Juglans mandshurica Maxim; green walnut husks; naphthoquinones; cytotoxic activity; structure-activity relationships
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Zhou, Y.; Yang, B.; Jiang, Y.; Liu, Z.; Liu, Y.; Wang, X.; Kuang, H. Studies on Cytotoxic Activity against HepG-2 Cells of Naphthoquinones from Green Walnut Husks of Juglans mandshurica Maxim. Molecules 2015, 20, 15572-15588.

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