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Molecules 2015, 20(9), 17483-17492; doi:10.3390/molecules200917483

Insecticidal Constituents and Activity of Alkaloids from Cynanchum mongolicum

1
College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China
2
Collaborative Innovation Center of Special Plant Industry, Chongqing University of Arts and Sciences, Chongqing 402160, China
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 16 July 2015 / Revised: 18 August 2015 / Accepted: 25 August 2015 / Published: 21 September 2015
(This article belongs to the Collection Bioactive Compounds)
View Full-Text   |   Download PDF [827 KB, uploaded 21 September 2015]   |  

Abstract

Based on MS and NMR data and bioassay-guided tracing, three insecticidal alkaloids I, II and III from Cynanchum mongolicum were identified to be antofine N-oxide, antofine and tylophorine. Alkaloid I was more toxic than alkaloids II and III, but they were less active against Spodoptera litura than total alkaloids. The contact toxicity from these alkaloids against the aphid Lipaphis erysimi was significant, as the 24 h-LC50 values of alkaloids I, II, III and total alkaloids were 292.48, 367.21, 487.791 and 163.52 mg/L, respectively. The development disruption of S. litura larvae was tested, the pupation and emergence rates of S. litura decreased and the acute mortality of S. litura increased significantly by day 3 after being injected in their body cavity with 10–40 mg/L of total alkaloid. The ecdysone titer of treated S. litura larvae and prepupae declined with increasing alkaloid concentration. The alkaloids of Cynanchum mongolicum are potential insect growth inhibitors. View Full-Text
Keywords: Cynanchum mongolicum; alkaloids; insecticidal constituents; insecticidal activity; Spodoptera litura; Lipaphis erysimi Cynanchum mongolicum; alkaloids; insecticidal constituents; insecticidal activity; Spodoptera litura; Lipaphis erysimi
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ge, Y.; Liu, P.; Yang, R.; Zhang, L.; Chen, H.; Camara, I.; Liu, Y.; Shi, W. Insecticidal Constituents and Activity of Alkaloids from Cynanchum mongolicum. Molecules 2015, 20, 17483-17492.

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