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Molecules 2015, 20(9), 15589-15596; doi:10.3390/molecules200915589

Identification of N-Acetyldopamine Dimers from the Dung Beetle Catharsius molossus and Their COX-1 and COX-2 Inhibitory Activities

1
School of Medicine, Sichuan Medical University, 319 Zhongshan Road, Luzhou 646000, China
2
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 132 Lanhei Road, Kunming 650201, China
3
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Road, Guangzhou 510530, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 7 July 2015 / Revised: 10 August 2015 / Accepted: 17 August 2015 / Published: 27 August 2015
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [755 KB, uploaded 27 August 2015]   |  

Abstract

Recent studies focusing on identifying the biological agents of Catharsius molossus have led to the identification of three new N-acetyldopamine dimers molossusamide A–C (1-3) and two known compounds 4 and 5. The structures of the new compounds were identified by comprehensive spectroscopic evidences. Compound 4 was found to have inhibitory effects towards COX-1 and COX-2. View Full-Text
Keywords: Catharsius molossus; N-acetyldopamine dimers; COX-1; COX-2 Catharsius molossus; N-acetyldopamine dimers; COX-1; COX-2
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Lu, J.; Sun, Q.; Tu, Z.-C.; Lv, Q.; Shui, P.-X.; Cheng, Y.-X. Identification of N-Acetyldopamine Dimers from the Dung Beetle Catharsius molossus and Their COX-1 and COX-2 Inhibitory Activities. Molecules 2015, 20, 15589-15596.

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