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Molecules 2015, 20(8), 15330-15342; doi:10.3390/molecules200815330

α-Glucosidase Inhibitors from Vauquelinia corymbosa

1
Facultad de Química, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico
2
Instituto de Biología, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico
*
Author to whom correspondence should be addressed.
Academic Editor: Isabel C. F. R. Ferreira
Received: 4 July 2015 / Revised: 15 August 2015 / Accepted: 18 August 2015 / Published: 21 August 2015
(This article belongs to the Collection Bioactive Compounds)
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Abstract

The α-glucosidase inhibitory activity of an aqueous extract and compounds from the aerial parts of V. corymbosa was demonstrated with yeast and rat small intestinal α-glucosidases. The aqueous extract inhibited yeast α-glucosidase with a half maximal inhibitory concentration (IC50) of 28.6 μg/mL. Bioassay-guided fractionation of the extract led to the isolation of several compounds, including one cyanogenic glycoside [prunasin (1)], five flavonoids [(−)-epi-catechin (2), hyperoside (3), isoquercetin (4), quercitrin (5) and quercetin-3-O-(6′′-benzoyl)-β-galactoside (6)] and two simple aromatic compounds [picein (7) and methylarbutin (8)]. The most active compound was 6 with IC50 values of 30 μM in the case of yeast α-glucosidase, and 437 μM in the case of the mammalian enzyme. According to the kinetic analyses performed with rat and yeast enzymes, this compound behaved as mixed-type inhibitor; the calculated inhibition constants (Ki) were 212 and 50 μM, respectively. Molecular docking analyses with yeast and mammalian α-glucosidases revealed that compound 6 bind differently to these enzymes. Altogether, the results of this work suggest that preparations of V. corymbosa might delay glucose absorption in vivo. View Full-Text
Keywords: diabetes; yeast and rat α-glucosidases; Vauquelinia corymbosa diabetes; yeast and rat α-glucosidases; Vauquelinia corymbosa
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MDPI and ACS Style

Flores-Bocanegra, L.; Pérez-Vásquez, A.; Torres-Piedra, M.; Bye, R.; Linares, E.; Mata, R. α-Glucosidase Inhibitors from Vauquelinia corymbosa. Molecules 2015, 20, 15330-15342.

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