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Molecules 2015, 20(8), 14950-14958; doi:10.3390/molecules200814950

Oral Intake of Carboxymethyl-Glucan (CM-G) from Yeast (Saccharomyces uvarum) Reduces Malondialdehyde Levels in Healthy Men

1
Laboratório de Bioquímica de Alimentos, Departamento de Engenharia de Alimentos, Universidade Federal da Paraíba, João Pessoa, Paraíba 58051-900, Brazil
2
Departamento de Ciência e Tecnologia de Alimentos, Universidade Estadual de Londrina, Paraná 8606970, Brazil
3
Departamento de Educação, Universidade Federal da Paraíba, João Pessoa, Paraíba 58051-900, Brazil
4
Laboratório de Microbiologia de Alimentos, Departmento de Nutrição, Universidade Federal da Paraíba, João Pessoa, Paraíba 58051-900, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 20 June 2015 / Revised: 10 August 2015 / Accepted: 12 August 2015 / Published: 14 August 2015
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [1652 KB, uploaded 14 August 2015]   |  

Abstract

Carboxymethyl-glucan (CM-G) is a water-soluble derivative of β(1→3)(1→6) glucan, a well-known immunostimulant and antioxidant compound. In this experimental, randomized and placebo-controlled study, the effects of oral CM-G intake over a 60-day period on the peripheral blood, cholesterol, glycemic index and malondialdehyde (MDA) levels of healthy men was assessed. The CM-G was obtained from spent brewer’s yeast (S. uvarum) with DS 0.8 and molecular weight of 2.2 × 105 Da. Following CM-G administration, no changes were observed in red and white blood cell, hematocrit, hemoglobin and platelet counts, or in cholesterol and glycemic indices. After 30 days of CM-G administration, the MDA levels decreased significantly (p ≤ 0.05) in men receiving CM-G. The results showed for the first time that CM-G may act as an adjuvant in preventing oxidative damage in healthy humans. View Full-Text
Keywords: carboxymethyl-glucan; glucan-derivatives; malondialdehyde; blood cells carboxymethyl-glucan; glucan-derivatives; malondialdehyde; blood cells
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Araújo, V.B.S.; de Melo, A.N.F.; de Souza, N.T.; da Silva, V.M.B.; Castro-Gomez, R.H.; Silva, A.S.; de Souza, E.L.; Magnani, M. Oral Intake of Carboxymethyl-Glucan (CM-G) from Yeast (Saccharomyces uvarum) Reduces Malondialdehyde Levels in Healthy Men. Molecules 2015, 20, 14950-14958.

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