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Molecules 2015, 20(8), 14118-14138; doi:10.3390/molecules200814118

Search for Antiprotozoal Activity in Herbal Medicinal Preparations; New Natural Leads against Neglected Tropical Diseases

1
Institut für Pharmazeutische Biologie und Phytochemie (IPBP), University of Münster, PharmaCampus, Corrensstraße 48, D-48149 Münster, Germany
2
Swiss Tropical and Public Health Institute (Swiss TPH), Socinstraße 57, CH-4002 Basel, Switzerland
3
University of Basel, Petersplatz 1, CH-4003 Basel, Switzerland
Part of the doctoral thesis of N.L.M. This work has been presented in the Young Researcher Meeting, Münster, Germany, 13–14 March 2015.
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 27 June 2015 / Revised: 21 July 2015 / Accepted: 28 July 2015 / Published: 4 August 2015
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Abstract

Sleeping sickness, Chagas disease, Leishmaniasis, and Malaria are infectious diseases caused by unicellular eukaryotic parasites (“protozoans”). The three first mentioned are classified as Neglected Tropical Diseases (NTDs) by the World Health Organization and together threaten more than one billion lives worldwide. Due to the lack of research interest and the high increase of resistance against the existing treatments, the search for effective and safe new therapies is urgently required. In view of the large tradition of natural products as sources against infectious diseases [1,2], the aim of the present study is to investigate the potential of legally approved and marketed herbal medicinal products (HMPs) as antiprotozoal agents. Fifty-eight extracts from 53 HMPs on the German market were tested by a Multiple-Target-Screening (MTS) against parasites of the genera Leishmania, Trypanosoma, and Plasmodium. Sixteen HMPs showed in vitro activity against at least one of the pathogens (IC50 < 10 µg/mL). Six extracts from preparations of Salvia, Valeriana, Hypericum, Silybum, Arnica, and Curcuma exhibited high activity (IC50 < 2.5 µg/mL). They were analytically characterized by UHPLC/ESI-QqTOF-MSMS and the activity-guided fractionation of the extracts with the aim to isolate and identify the active compounds is in progress. View Full-Text
Keywords: neglected tropical diseases; antiprotozoal activity; Plasmodium falciparum; Trypanosoma cruzi; Trypanosoma brucei rhodesiense; Leishmania donovani; herbal medicinal preparations (HMPs) neglected tropical diseases; antiprotozoal activity; Plasmodium falciparum; Trypanosoma cruzi; Trypanosoma brucei rhodesiense; Leishmania donovani; herbal medicinal preparations (HMPs)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Llurba-Montesino, N.; Kaiser, M.; Brun, R.; Schmidt, T.J. Search for Antiprotozoal Activity in Herbal Medicinal Preparations; New Natural Leads against Neglected Tropical Diseases. Molecules 2015, 20, 14118-14138.

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