Next Article in Journal
Graphene-Based Nanomaterials as Efficient Peroxidase Mimetic Catalysts for Biosensing Applications: An Overview
Previous Article in Journal
Search for Antiprotozoal Activity in Herbal Medicinal Preparations; New Natural Leads against Neglected Tropical Diseases
Article Menu

Export Article

Open AccessCommunication
Molecules 2015, 20(8), 14139-14154; doi:10.3390/molecules200814139

Synthesis and Herbicidal Activity of New Hydrazide and Hydrazonoyl Derivatives

1
Institute of Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina, Bratislava 842 15, Slovakia
2
Department of Chemistry, Faculty of Natural Sciences, Matej Bell University, Tajovského 40, Banská Bystrica 974 01, Slovakia
3
Department of Environmental Ecology, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina, Bratislava 842 15, Slovakia
4
Institute of Physical Chemistry and Chemical Physics, Faculty Chemical and Food Technology, Slovak University of Technology in Bratislava, Radlinského 9, Bratislava 812 37, Slovakia
5
Department of Genetics, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina, Bratislava 842 15, Slovakia
6
Department of Chromosome Biology, MFPL, University of Vienna, Dr. Bohr-Gasse 7, Vienna 1030, Austria
*
Author to whom correspondence should be addressed.
Academic Editor: Roman Dembinski
Received: 18 June 2015 / Revised: 30 July 2015 / Accepted: 31 July 2015 / Published: 4 August 2015
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [1044 KB, uploaded 4 August 2015]   |  

Abstract

Three new hydrazide and five new hydrazonoyl derivatives were synthesized. The chemical structures of these compounds were confirmed by 1H-NMR, IR spectroscopy and elemental analysis. The prepared compounds were tested for their activity to inhibit photosynthetic electron transport in spinach chloroplasts and growth of the green algae Chlorella vulgaris. IC50 values of these compounds varied in wide range, from a strong to no inhibitory effect. EPR spectroscopy showed that the active compounds interfered with intermediates Z/D, which are localized on the donor side of photosystem II. Fluorescence spectroscopy suggested that the mechanism of inhibitory action of the prepared compounds possibly involves interactions with aromatic amino acids present in photosynthetic proteins. View Full-Text
Keywords: green algae; N′-[2,6-dinitro-4-(trifluoromethyl)phenyl]hydrazides; N′-[2,6-dinitro-4-[trifluoromethyl)phenyl]hydrazonoyl derivatives; photosynthesis inhibition; spinach chloroplasts green algae; N′-[2,6-dinitro-4-(trifluoromethyl)phenyl]hydrazides; N′-[2,6-dinitro-4-[trifluoromethyl)phenyl]hydrazonoyl derivatives; photosynthesis inhibition; spinach chloroplasts
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Šeršeň, F.; Gregáň, F.; Peško, M.; Dvoranová, D.; Kráľová, K.; Matkovičová, Z.; Gregáň, J.; Donovalová, J. Synthesis and Herbicidal Activity of New Hydrazide and Hydrazonoyl Derivatives. Molecules 2015, 20, 14139-14154.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top