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Molecules 2015, 20(7), 12992-13004; doi:10.3390/molecules200712992

Phytochemical Properties and Anti-Proliferative Activity of Olea europaea L. Leaf Extracts against Pancreatic Cancer Cells

1
Nutrition Food & Health Research Group, School of Environmental and Life Sciences, University of Newcastle, Ourimbah, NSW 2258, Australia
2
School of Biomedical Sciences and Pharmacy, University of Newcastle, Ourimbah, NSW 2258, Australia
3
Faculty of Bioscience Engineering, Ghent University Global Campus, Incheon 406-840, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Marcello Iriti
Received: 29 May 2015 / Revised: 13 July 2015 / Accepted: 14 July 2015 / Published: 17 July 2015
View Full-Text   |   Download PDF [1008 KB, uploaded 17 July 2015]   |  

Abstract

Olea europaea L. leaves are an agricultural waste product with a high concentration of phenolic compounds; especially oleuropein. Oleuropein has been shown to exhibit anti-proliferative activity against a number of cancer types. However, they have not been tested against pancreatic cancer, the fifth leading cause of cancer related death in Western countries. Therefore, water, 50% ethanol and 50% methanol extracts of Corregiola and Frantoio variety Olea europaea L. leaves were investigated for their total phenolic compounds, total flavonoids and oleuropein content, antioxidant capacity and anti-proliferative activity against MiaPaCa-2 pancreatic cancer cells. The extracts only had slight differences in their phytochemical properties, and at 100 and 200 μg/mL, all decreased the viability of the pancreatic cancer cells relative to controls. At 50 μg/mL, the water extract from the Corregiola leaves exhibited the highest anti-proliferative activity with the effect possibly due to early eluting HPLC peaks. For this reason, olive leaf extracts warrant further investigation into their potential anti-pancreatic cancer benefits. View Full-Text
Keywords: olive leaf; oleuropein; pancreatic cancer; phenolic compounds; Olea europaea L.; antioxidant activity; phytochemicals; biophenols olive leaf; oleuropein; pancreatic cancer; phenolic compounds; Olea europaea L.; antioxidant activity; phytochemicals; biophenols
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Goldsmith, C.D.; Vuong, Q.V.; Sadeqzadeh, E.; Stathopoulos, C.E.; Roach, P.D.; Scarlett, C.J. Phytochemical Properties and Anti-Proliferative Activity of Olea europaea L. Leaf Extracts against Pancreatic Cancer Cells. Molecules 2015, 20, 12992-13004.

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