Next Article in Journal
Recent Developments and Biological Activities of N-Substituted Carbazole Derivatives: A Review
Next Article in Special Issue
Metabolic Analysis of Various Date Palm Fruit (Phoenix dactylifera L.) Cultivars from Saudi Arabia to Assess Their Nutritional Quality
Previous Article in Journal
Molecular Docking and Structure-Based Drug Design Strategies
Previous Article in Special Issue
Phytochemical Properties and Anti-Proliferative Activity of Olea europaea L. Leaf Extracts against Pancreatic Cancer Cells
Article Menu

Export Article

Open AccessReview
Molecules 2015, 20(7), 13422-13495; doi:10.3390/molecules200713422

Secondary Metabolites from Rubiaceae Species

Bioprospection and Biotechnology Laboratory, Technology and Innovation Coordenation, National Research Institute of Amazonia, Av. André Araújo, 2936, Petrópolis, Manaus, AM 69067-375, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Marcello Iriti
Received: 13 June 2015 / Revised: 11 July 2015 / Accepted: 13 July 2015 / Published: 22 July 2015
View Full-Text   |   Download PDF [1216 KB, uploaded 22 July 2015]   |  

Abstract

This study describes some characteristics of the Rubiaceae family pertaining to the occurrence and distribution of secondary metabolites in the main genera of this family. It reports the review of phytochemical studies addressing all species of Rubiaceae, published between 1990 and 2014. Iridoids, anthraquinones, triterpenes, indole alkaloids as well as other varying alkaloid subclasses, have shown to be the most common. These compounds have been mostly isolated from the genera Uncaria, Psychotria, Hedyotis, Ophiorrhiza and Morinda. The occurrence and distribution of iridoids, alkaloids and anthraquinones point out their chemotaxonomic correlation among tribes and subfamilies. From an evolutionary point of view, Rubioideae is the most ancient subfamily, followed by Ixoroideae and finally Cinchonoideae. The chemical biosynthetic pathway, which is not so specific in Rubioideae, can explain this and large amounts of both iridoids and indole alkaloids are produced. In Ixoroideae, the most active biosysthetic pathway is the one that produces iridoids; while in Cinchonoideae, it produces indole alkaloids together with other alkaloids. The chemical biosynthetic pathway now supports this botanical conclusion. View Full-Text
Keywords: Rubiaceae; Rubioideae; Cinchonoideae; Ixoroideae; iridoids; alkaloid; anthraquinones; triterpenes Rubiaceae; Rubioideae; Cinchonoideae; Ixoroideae; iridoids; alkaloid; anthraquinones; triterpenes
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Martins, D.; Nunez, C.V. Secondary Metabolites from Rubiaceae Species. Molecules 2015, 20, 13422-13495.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top