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Molecules 2015, 20(7), 12512-12524; doi:10.3390/molecules200712512

Pro-Angiogenic Effects of Chalcone Derivatives in Zebrafish Embryos in Vivo

1
Department of Chemistry, Tamkang University, 151, Ying-chuan Road, Danshui District, New Taipei City 25137, Taiwan
2
Department of Life Sciences, National Chung Hsing University, Taichung 40227, Taiwan
3
Department of Applied Chemistry, National Chia-Yi University, Chia-Yi 60004, Taiwan
4
School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung 40201, Taiwan
5
Clinical Laboratory, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 20 April 2015 / Revised: 3 July 2015 / Accepted: 6 July 2015 / Published: 9 July 2015
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [1441 KB, uploaded 9 July 2015]   |  

Abstract

The aim of this study was to investigate novel chalcones with potent angiogenic activities in vivo. Chalcone-based derivatives were evaluated using a transgenic zebrafish line with fluorescent vessels to real-time monitor the effect on angiogenesis. Results showed that the chalcone analogues did not possess anti-angiogenic effect on zebrafish vasculatures; instead, some of them displayed potent pro-angiogenic effects on the formation of the sub-intestinal vein. Similar pro-angiogenic effects can also be seen on wild type zebrafish embryos. Moreover, the expression of vegfa, the major regulator for angiogenesis, was also upregulated in their treatment. Taken together, we have synthesized and identified a series of novel chalcone-based derivatives as potent in vivo pro-angiogenic compounds. These novel compounds hold potential for therapeutic angiogenesis. View Full-Text
Keywords: angiogenesis; chalcones; in vivo; zebrafish embryos angiogenesis; chalcones; in vivo; zebrafish embryos
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Chen, Y.-H.; Chang, C.-Y.; Chang, C.-F.; Chen, P.-C.; Lee, Y.-T.; Chern, C.-Y.; Tsai, J.-N. Pro-Angiogenic Effects of Chalcone Derivatives in Zebrafish Embryos in Vivo. Molecules 2015, 20, 12512-12524.

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