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Molecules 2015, 20(7), 12500-12511; doi:10.3390/molecules200712500

Constituents of Psoralea corylifolia Fruits and Their Effects on Methicillin-Resistant Staphylococcus aureus

1
Department of Natural Product Chemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Tsushima-naka, Kita-ku, Okayama 700-8530, Japan
2
Drug Discovery Technology Center, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Tsushima-naka, Kita-ku, Okayama 700-8530, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 1 June 2015 / Revised: 1 July 2015 / Accepted: 2 July 2015 / Published: 9 July 2015
(This article belongs to the Section Natural Products)
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Abstract

Two new flavonoids, bakuisoflavone (1) and bakuflavanone (2), together with 15 known compounds, were isolated from the fruits of Psoralea corylifolia, and their structures were characterized by spectroscopic data. The effects of the isolated compounds on methicillin-resistant Staphylococcus aureus were also examined. We found that two compounds, isobavachalcone (10) and bakuchiol (12), showed noticeable antibacterial effects on the MRSA strains examined. Quantitation of the major constituents, including anti-MRSA constituents, was then performed. The results showed individual contents of 1.26%–16.49% (w/w) among the examined compounds in the ethyl acetate extract from P. corylifolia fruits. View Full-Text
Keywords: Psoralea corylifolia; bakuisoflavone; bakuflavanone; methicillin-resistant Staphylococcus aureus Psoralea corylifolia; bakuisoflavone; bakuflavanone; methicillin-resistant Staphylococcus aureus
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Cui, Y.; Taniguchi, S.; Kuroda, T.; Hatano, T. Constituents of Psoralea corylifolia Fruits and Their Effects on Methicillin-Resistant Staphylococcus aureus. Molecules 2015, 20, 12500-12511.

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