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Molecules 2015, 20(7), 12300-12313; doi:10.3390/molecules200712300

Heterocycles 38. Biocatalytic Synthesis of New Heterocyclic Mannich Bases and Derivatives

1
Department of Organic Chemistry, "Iuliu Haţieganu" University of Medicine and Pharmacy, 41 Victor Babeş street, RO-400012 Cluj-Napoca, Romania
2
Department of Biochemistry and Biochemical Engineering, Babeş-Bolyai University of Cluj-Napoca, 11 Arany János street, RO-400028 Cluj-Napoca, Romania
*
Author to whom correspondence should be addressed.
Academic Editor: Wim Dehaen
Received: 2 June 2015 / Revised: 1 July 2015 / Accepted: 2 July 2015 / Published: 6 July 2015
(This article belongs to the Collection Heterocyclic Compounds)
View Full-Text   |   Download PDF [842 KB, uploaded 6 July 2015]   |  

Abstract

This paper describes the biocatalytic synthesis of new Mannich bases containing various heterocyclic rings (thiazole, furane, thiophene, pyridine) by applying the lipase catalyzed trimolecular condensation of the corresponding heterocyclic aldehydes with acetone and primary aromatic amines, in mild and eco-friendly reaction conditions. The obtained Mannich bases were acylated to their corresponding N-acetyl derivatives. All compounds were characterized by 1H-NMR, 13C-NMR and MS spectrometry. View Full-Text
Keywords: Mannich reaction; heterocyclic compounds; lipase; biocatalytic promiscuity Mannich reaction; heterocyclic compounds; lipase; biocatalytic promiscuity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Leonte, D.; Bencze, L.C.; Paizs, C.; Irimie, F.D.; Zaharia, V. Heterocycles 38. Biocatalytic Synthesis of New Heterocyclic Mannich Bases and Derivatives. Molecules 2015, 20, 12300-12313.

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