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Molecules 2015, 20(6), 9949-9960; doi:10.3390/molecules20069949

Microwave-Assisted Resolution of α-Lipoic Acid Catalyzed by an Ionic Liquid Co-Lyophilized Lipase

1
Central Laboratory, The Second Hospital of Jilin University, Changchun 130021, China
2
Key Laboratory of Molecular Enzymology and Engineering of Ministry of Education, College of Life Science, Jilin University, Changchun 130012, China
3
The First Hospital of Jilin University, Changchun 130021, China
*
Author to whom correspondence should be addressed.
Academic Editor: Raquel P. Herrera
Received: 17 April 2015 / Revised: 18 May 2015 / Accepted: 19 May 2015 / Published: 29 May 2015
(This article belongs to the Collection Recent Advances in Organocatalysis)
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Abstract

The combination of the ionic liquid co-lyophilized lipase and microwave irradiation was used to improve enzyme performance in enantioselective esterification of α-lipoic acid. Effects of various reaction conditions on enzyme activity and enantioselectivity were investigated. Under optimal condition, the highest enantioselectivity (E = 41.2) was observed with a high enzyme activity (178.1 μmol/h/mg) when using the ionic liquid co-lyophilized lipase with microwave assistance. Furthermore, the ionic liquid co-lyophilized lipase exhibited excellent reusability under low power microwave. View Full-Text
Keywords: ionic liquid co-lyophilized lipase; α-lipoic acid; enantioselectivity; enzyme activity; esterification; microwave ionic liquid co-lyophilized lipase; α-lipoic acid; enantioselectivity; enzyme activity; esterification; microwave
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Liu, N.; Wang, L.; Wang, Z.; Jiang, L.; Wu, Z.; Yue, H.; Xie, X. Microwave-Assisted Resolution of α-Lipoic Acid Catalyzed by an Ionic Liquid Co-Lyophilized Lipase. Molecules 2015, 20, 9949-9960.

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