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Molecules 2015, 20(5), 8574-8582; doi:10.3390/molecules20058574

Highly Diastereoselective Synthesis of Spiropyrazolones

1
Faculty of Natural & Environmental Sciences, University of Southampton Highfield Campus, Southampton SO17 1BJ, UK
2
Department of Chemistry, Obafemi Awolowo University, Ile-Ife 220005, Nigeria
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Raquel P. Herrera
Received: 28 April 2015 / Revised: 8 May 2015 / Accepted: 11 May 2015 / Published: 13 May 2015
(This article belongs to the Collection Recent Advances in Organocatalysis)
View Full-Text   |   Download PDF [857 KB, uploaded 13 May 2015]   |  

Abstract

We report a highly diastereoselective synthesis of spiropyrazolones catalyzed by secondary amines. The reported Michael-Aldol cascade reaction affords the desired spiropyrazolones bearing four chiral centers as a single diastereomer in excellent yields. View Full-Text
Keywords: spiropyrazolones; diastereoselective; cascade reaction spiropyrazolones; diastereoselective; cascade reaction
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ceban, V.; Olomola, T.O.; Meazza, M.; Rios, R. Highly Diastereoselective Synthesis of Spiropyrazolones. Molecules 2015, 20, 8574-8582.

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