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Molecules 2015, 20(6), 11202-11218; doi:10.3390/molecules200611202

Cornus mas (Linnaeus) Novel Devised Medicinal Preparations: Bactericidal Effect against Staphylococcus aureus and Pseudomonas aeruginosa

1
Nasco AD Biotechnology Laboratory, 11 Sachtouri Street, 18536 Pireus, Greece
2
Department of Chemistry, Tripura University, Suryamaninagar 799 022 Tripura, India
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 24 April 2015 / Revised: 8 June 2015 / Accepted: 12 June 2015 / Published: 17 June 2015
(This article belongs to the Section Medicinal Chemistry)
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Abstract

The medicinal properties of Cornus mas L. (=Cornus mascula L.), Cornaceae, are well described in Hippocratian documents, and recent research provides experimental evidence for some of these properties. However, the chemical components of Cornus mas L. that may be of pharmaceutical importance are relatively unstable. In this respect a novel methodology for plant nutrient element extraction that provides favorable conditions for simultaneous stabilization of such fragile and unstable structures has been devised. Using this methodology, medicinal preparations derived from Cornus mas L. fresh fruits, proved to possess significant antimicrobial activity selective against S. aureus and P. aeruginosa. This effect became apparent with the addition of sodium bromide in the extraction procedure and varied with the ion availability during extraction. The identification of novel agents with potent antimicrobial activity against these species is of medical importance to overcome the problem of universal antibiotic resistance. View Full-Text
Keywords: Cornus mas (L.) fresh fruits; novel medicinal preparations; selective bactericidal effect; Pseudomonas aeruginosa; Staphylococcus aureus Cornus mas (L.) fresh fruits; novel medicinal preparations; selective bactericidal effect; Pseudomonas aeruginosa; Staphylococcus aureus
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kyriakopoulos, A.M.; Dinda, B. Cornus mas (Linnaeus) Novel Devised Medicinal Preparations: Bactericidal Effect against Staphylococcus aureus and Pseudomonas aeruginosa. Molecules 2015, 20, 11202-11218.

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