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Molecules 2015, 20(6), 10622-10640; doi:10.3390/molecules200610622

Mucin-Type O-Glycosylation in Invertebrates

Department of Chemistry, University of Natural Resources and Life Sciences, Vienna, Muthgasse 18, 1190 Vienna, Austria
Academic Editor: Els van Damme
Received: 14 March 2015 / Revised: 1 June 2015 / Accepted: 3 June 2015 / Published: 9 June 2015
(This article belongs to the Special Issue Protein-Carbohydrate Interactions, and Beyond)
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Abstract

O-Glycosylation is one of the most important posttranslational modifications of proteins. It takes part in protein conformation, protein sorting, developmental processes and the modulation of enzymatic activities. In vertebrates, the basics of the biosynthetic pathway of O-glycans are already well understood. However, the regulation of the processes and the molecular aspects of defects, especially in correlation with cancer or developmental abnormalities, are still under investigation. The knowledge of the correlating invertebrate systems and evolutionary aspects of these highly conserved biosynthetic events may help improve the understanding of the regulatory factors of this pathway. Invertebrates display a broad spectrum of glycosylation varieties, providing an enormous potential for glycan modifications which may be used for the design of new pharmaceutically active substances. Here, overviews of the present knowledge of invertebrate mucin-type O-glycan structures and the currently identified enzymes responsible for the biosynthesis of these oligosaccharides are presented, and the few data dealing with functional aspects of O-glycans are summarised. View Full-Text
Keywords: O-glycosylation; invertebrates; mucin-type; nematode; insect; helminth; mollusc O-glycosylation; invertebrates; mucin-type; nematode; insect; helminth; mollusc
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Staudacher, E. Mucin-Type O-Glycosylation in Invertebrates. Molecules 2015, 20, 10622-10640.

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