Next Article in Journal
Functional Thermoplastic Materials from Derivatives of Cellulose and Related Structural Polysaccharides
Next Article in Special Issue
Evaluation of the Hypoglycemic Effects of Flavonoids and Extracts from Jatropha gossypifolia L.
Previous Article in Journal
Cytoprotective Effect of Hispidin against Palmitate-Induced Lipotoxicity in C2C12 Myotubes
Previous Article in Special Issue
Economical Synthesis of 13C-Labeled Opiates, Cocaine Derivatives and Selected Urinary Metabolites by Derivatization of the Natural Products
Article Menu

Export Article

Open AccessArticle
Molecules 2015, 20(4), 5468-5486; doi:10.3390/molecules20045468

Stevia Rebaudiana Bert. Leaf Extracts as a Multifunctional Source of Natural Antioxidants

1
Department of Public Health, Dietetics & Lifestyle Disorders, The University of Information Technology and Management in Rzeszow, Kielnarowa 386a, Tyczyn 36-020, Poland
2
Department of Cosmetology, The University of Information Technology and Management in Rzeszow, Kielnarowa 386a, Tyczyn 36-020, Poland
3
Department of Biochemistry and Food Chemistry, The University of Life Sciences, Skromna Street 8, Lublin 20-704, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Isabel C. F. R. Ferreira
Received: 4 December 2014 / Revised: 13 February 2015 / Accepted: 28 February 2015 / Published: 27 March 2015
(This article belongs to the Collection Bioactive Compounds)
View Full-Text   |   Download PDF [3145 KB, uploaded 27 March 2015]   |  

Abstract

The aim of the presented study was to characterize the content and biological activity of extracts prepared from dried Stevia rebaudiana leaves with potential application in the food or cosmetic industry. Aqueous (A), ethanolic (E) and glycol-aqueous (GA) extracts were analyzed for the content of polyphenols and proteins, showing that the highest amount of phenols (15.50 mg/g) and flavonoids (3.85 mg/g) contained GA. All extracts contained significant amount of protein (69.40–374.67 mg/g). Between analyzed stevia extracts (HPLC) GA contained the highest amount of polyphenols, especially ferulic (5.50 mg/g) and rozmaric (4.95 mg/g) acids derivates. The highest antiradical activity against DPPH and ABTS•+ was noted for GA and E (IC50 = 0.38 and 0.71 µg flavonoids/mL). The highest ability to chelate Fe2+ was observed for E (IC50 = 2.08 µg flavonoids/mL). Stevia extracts were also analyzed for their cytotoxicity and fibroblast irritation potential in vitro. E and GA were the most cytotoxic and irritating, probably due to the high content of biologically active phytochemicals. On the other hand, a extract was the most tolerable by the cells. To summarize, the presented study evaluated the potential application of A, E and GA stevia extracts as natural source of antioxidants in the food and cosmetic industry. View Full-Text
Keywords: Stevia rebaudiana; polyphenols; free radical scavenging; iron (II) ion chelating; cytotoxicity; fibroblasts Stevia rebaudiana; polyphenols; free radical scavenging; iron (II) ion chelating; cytotoxicity; fibroblasts
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Gaweł-Bęben, K.; Bujak, T.; Nizioł-Łukaszewska, Z.; Antosiewicz, B.; Jakubczyk, A.; Karaś, M.; Rybczyńska, K. Stevia Rebaudiana Bert. Leaf Extracts as a Multifunctional Source of Natural Antioxidants. Molecules 2015, 20, 5468-5486.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top