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Molecules 2015, 20(4), 6181-6193; doi:10.3390/molecules20046181

Evaluation of the Hypoglycemic Effects of Flavonoids and Extracts from Jatropha gossypifolia L.

1
Grupo de Genética Molecular y Departamento de Fisiología y Bioquímica, Facultad de Medicina, Universidad de Antioquia, Calle 67 No. 53-10, Medellín 050010, Colombia
2
Grupo de Quimica Orgánica de Productos Naturales, Instituto de Química, Universidad de Antioquia, Calle 67 No. 53-10, Medellín 050010, Colombia
*
Author to whom correspondence should be addressed.
Academic Editor: Isabel C. F. R. Ferreira
Received: 23 January 2015 / Revised: 19 March 2015 / Accepted: 23 March 2015 / Published: 9 April 2015
(This article belongs to the Collection Bioactive Compounds)
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Abstract

Jatropha gossypifolia L. (Euphorbiaceae) is a plant widely used in the treatment of type 2 diabetes mellitus (T2DM), but there are few scientific reports validating its activity in this area. In this work and through a bioguided assay, a crude extract stimulated glucose uptake in C2C12 myotubes up to 30%, thereby reducing insulin resistance induced by fatty acids compared to the basal control. A chromatographic fraction applied intraperitoneally (IP) in mice reduced glucose by 42% in a mouse model of T2DM, after administration of 10 doses during 20 days. A flavanone was purified from this active fraction and its structure was assigned by 1H- and 13C-NMR (1D and 2D) and MS. This compound retains the previously reported activity, stimulating in vitro the glucose uptake in a concentration-dependent manner. This study indicates that Jatropha gossypifolia L. extracts enhance glucose uptake in cultured myotubes and adipocytes and also improving glucose tolerance in an in vivo model. View Full-Text
Keywords: Jatropha gossypifolia L.; flavanone; flavone; glucose regulation; myotubes; mice Jatropha gossypifolia L.; flavanone; flavone; glucose regulation; myotubes; mice
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MDPI and ACS Style

Granados, S.; Balcázar, N.; Guillén, A.; Echeverri, F. Evaluation of the Hypoglycemic Effects of Flavonoids and Extracts from Jatropha gossypifolia L.. Molecules 2015, 20, 6181-6193.

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