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Molecules 2015, 20(4), 5456-5467; doi:10.3390/molecules20045456

Cytoprotective Effect of Hispidin against Palmitate-Induced Lipotoxicity in C2C12 Myotubes

1
Department of Bioengineering and Technology, Kangwon National University, Chuncheon, Gangwon-do 200-701, Korea
2
National Institute of Biological Resources, Incheon 404-708, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 9 February 2015 / Revised: 23 March 2015 / Accepted: 24 March 2015 / Published: 27 March 2015
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [1235 KB, uploaded 27 March 2015]   |  

Abstract

It is well known that Phellinus linteus, which produces hispidin and its derivatives, possesses antioxidant activities. In this study, we investigated whether hispidin has protective effects on palmitate-induced oxidative stress in C2C12 skeletal muscle cells. Our results showed that palmitate treatment in C2C12 myotubes increased ROS generation and cell death as compared with the control. However, pretreatment of hispidin for 8 h improved the survival of C2C12 myotubes against palmitate-induced oxidative stress via inhibition of intracellular ROS production. Hispidin also inhibited palmitate-induced apoptotic nuclear condensation in C2C12 myotubes. In addition, we found that hispidin can suppress cleavage of caspase-3, expression of Bax, and NF-κB translocation. Therefore, these results suggest that hispidin is capable of protecting C2C12 myotubes against palmitate-induced oxidative stress. View Full-Text
Keywords: hispidin; oxidative stress; type 2 diabetes; C2C12 skeletal muscle cells; Phellinus linteus hispidin; oxidative stress; type 2 diabetes; C2C12 skeletal muscle cells; Phellinus linteus
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Park, J.M.; Lee, J.S.; Song, J.E.; Sim, Y.C.; Ha, S.-J.; Hong, E.K. Cytoprotective Effect of Hispidin against Palmitate-Induced Lipotoxicity in C2C12 Myotubes. Molecules 2015, 20, 5456-5467.

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