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Molecules 2015, 20(3), 4109-4123; doi:10.3390/molecules20034109

Nitric Oxide Released from Luminal S-Nitroso-N-Acetylcysteine Increases Gastric Mucosal Blood Flow

1
Institute of Chemistry, University of Campinas, UNICAMP, CP 6154, Campinas, SP 13083-970, Brazil
2
Faculty of Medical Sciences, University of Campinas, UNICAMP, CP, Campinas, SP 13084-970, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Claudio Battilocchio
Received: 22 December 2014 / Revised: 18 February 2015 / Accepted: 26 February 2015 / Published: 4 March 2015
(This article belongs to the Special Issue Nitric Oxide (NO) Release Chemistry)
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Abstract

Nitric oxide (NO)-mediated vasodilation plays a key role in gastric mucosal defense, and NO-donor drugs may protect against diseases associated with gastric mucosal blood flow (GMBF) deficiencies. In this study, we used the ex vivo gastric chamber method and Laser Doppler Flowmetry to characterize the effects of luminal aqueous NO-donor drug S-nitroso-N-acetylcysteine (SNAC) solution administration compared to aqueous NaNO2 and NaNO3 solutions (pH 7.4) on GMBF in Sprague-Dawley rats. SNAC solutions (600 μM and 12 mM) led to a rapid threefold increase in GMBF, which was maintained during the incubation of the solutions with the gastric mucosa, while NaNO2 or NaNO3 solutions (12 mM) did not affect GMBF. SNAC solutions (600 μM and 12 mM) spontaneously released NO at 37 °C at a constant rate of 0.3 or 14 nmol·mL−1·min−1, respectively, while NaNO2 (12 mM) released NO at a rate of 0.06 nmol·mL−1·min−1 and NaNO3 (12 mM) did not release NO. These results suggest that the SNAC-induced GMBF increase is due to their higher rates of spontaneous NO release compared to equimolar NaNO2 solutions. Taken together, our data indicate that oral SNAC administration is a potential approach for gastric acid-peptic disorder prevention and treatment. View Full-Text
Keywords: nitric oxide; S-nitroso-N-acetylcysteine; gastric blood flow; vasodilation nitric oxide; S-nitroso-N-acetylcysteine; gastric blood flow; vasodilation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

de Souza, G.F.P.; Taladriz-Blanco, P.; Velloso, L.A.; de Oliveira, M.G. Nitric Oxide Released from Luminal S-Nitroso-N-Acetylcysteine Increases Gastric Mucosal Blood Flow. Molecules 2015, 20, 4109-4123.

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