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Molecules 2015, 20(4), 5667-5679; doi:10.3390/molecules20045667

Nitric Oxide Donors and Selective Carbonic Anhydrase Inhibitors: A Dual Pharmacological Approach for the Treatment of Glaucoma, Cancer and Osteoporosis

1
Department of Pharmacy, "G. D'Annunzio" University of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy
2
Department of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy
3
Laboratorio di Chimica Bioinorganica, Università degli Studi di Firenze, Via della Lastruccia 3, 50019 Sesto Fiorentino (Firenze), Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Claudio Battilocchio
Received: 23 February 2015 / Revised: 15 March 2015 / Accepted: 24 March 2015 / Published: 31 March 2015
(This article belongs to the Special Issue Nitric Oxide (NO) Release Chemistry)
View Full-Text   |   Download PDF [658 KB, uploaded 14 April 2015]   |  

Abstract

Due to the recognized biological role of nitric oxide (NO) donating derivatives and of selective inhibitors of specific human carbonic anhydrase isoforms (CA, EC 4.2.1.1), promising compounds having an aromatic/heterocyclic primary sulfonamide and functionalized with NO-releasing moieties have been designed. These bifunctional agents have been tested in vitro and in vivo to assess their dual pharmacological activity. According to the encouraging results they could be proposed for the treatment of angle-open glaucoma, cancer regression and osteoporosis, in which both NO and CA activities are involved. View Full-Text
Keywords: NO donors; selective carbonic anhydrase inhibitors; glaucoma; cancer; osteoporosis; dual pharmacological activity NO donors; selective carbonic anhydrase inhibitors; glaucoma; cancer; osteoporosis; dual pharmacological activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Carradori, S.; Mollica, A.; De Monte, C.; Granese, A.; Supuran, C.T. Nitric Oxide Donors and Selective Carbonic Anhydrase Inhibitors: A Dual Pharmacological Approach for the Treatment of Glaucoma, Cancer and Osteoporosis. Molecules 2015, 20, 5667-5679.

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