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Molecules 2015, 20(3), 4124-4135; doi:10.3390/molecules20034124

Carbopol-Incorporated Thermoreversible Gel for Intranasal Drug Delivery

College of Pharmacy, Hanyang University, Ansan 426-791, Korea
Department of Organic Material Science & Engineering, Pusan National University, Busan 609-735, Korea
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151-742, Korea
College of Pharmacy, Kangwon National University, Chuncheon 200-701, Korea
College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon 200-701, Korea
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 21 January 2015 / Revised: 27 February 2015 / Accepted: 2 March 2015 / Published: 4 March 2015
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [967 KB, uploaded 4 March 2015]   |  


The present study describes the preparation and evaluation of a poloxamer 407 (P407)-based thermoreversible gel using Carbopol 934P (C934P) as a mucoadhesive polymer and hydroxypropyl-β-cyclodextrin (HP-β-CD) for enhancing the aqueous solubility and intranasal absorption of fexofenadine hydrochloride (FXD HCl). The prepared gels were characterized by gelation temperature, viscoelasticity, and drug release profile. Thermoreversibility of P407/C934P gel was demonstrated by rheological studies. The incorporation of carbopol into P407 gel also reduced the amounts of drug released from the gel formulations (p < 0.05). In vivo pharmacokinetic results of the prepared gel formulations in rabbits (at 0.5 mg/kg dose) showed that the relative bioavailability of drug from P407/C934P gel was 11.3 and 2.7-fold higher than those of drug solution and P407 gel group, respectively. These findings suggested that developed thermoreversible gels could be used as promising dosage forms to improve intranasal drug absorption. View Full-Text
Keywords: fexofenadine hydrochloride; nasal delivery; thermoreversibility; poloxamer; carbopol; bioavailability fexofenadine hydrochloride; nasal delivery; thermoreversibility; poloxamer; carbopol; bioavailability

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Balakrishnan, P.; Park, E.-K.; Song, C.-K.; Ko, H.-J.; Hahn, T.-W.; Song, K.-W.; Cho, H.-J. Carbopol-Incorporated Thermoreversible Gel for Intranasal Drug Delivery. Molecules 2015, 20, 4124-4135.

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