Next Article in Journal
DNA-Catalyzed Henry Reaction in Pure Water and the Striking Influence of Organic Buffer Systems
Previous Article in Journal
Nitric Oxide Released from Luminal S-Nitroso-N-Acetylcysteine Increases Gastric Mucosal Blood Flow
Article Menu

Export Article

Open AccessArticle
Molecules 2015, 20(3), 4124-4135; doi:10.3390/molecules20034124

Carbopol-Incorporated Thermoreversible Gel for Intranasal Drug Delivery

1
College of Pharmacy, Hanyang University, Ansan 426-791, Korea
2
Department of Organic Material Science & Engineering, Pusan National University, Busan 609-735, Korea
3
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151-742, Korea
4
College of Pharmacy, Kangwon National University, Chuncheon 200-701, Korea
5
College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon 200-701, Korea
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 21 January 2015 / Revised: 27 February 2015 / Accepted: 2 March 2015 / Published: 4 March 2015
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [967 KB, uploaded 4 March 2015]   |  

Abstract

The present study describes the preparation and evaluation of a poloxamer 407 (P407)-based thermoreversible gel using Carbopol 934P (C934P) as a mucoadhesive polymer and hydroxypropyl-β-cyclodextrin (HP-β-CD) for enhancing the aqueous solubility and intranasal absorption of fexofenadine hydrochloride (FXD HCl). The prepared gels were characterized by gelation temperature, viscoelasticity, and drug release profile. Thermoreversibility of P407/C934P gel was demonstrated by rheological studies. The incorporation of carbopol into P407 gel also reduced the amounts of drug released from the gel formulations (p < 0.05). In vivo pharmacokinetic results of the prepared gel formulations in rabbits (at 0.5 mg/kg dose) showed that the relative bioavailability of drug from P407/C934P gel was 11.3 and 2.7-fold higher than those of drug solution and P407 gel group, respectively. These findings suggested that developed thermoreversible gels could be used as promising dosage forms to improve intranasal drug absorption. View Full-Text
Keywords: fexofenadine hydrochloride; nasal delivery; thermoreversibility; poloxamer; carbopol; bioavailability fexofenadine hydrochloride; nasal delivery; thermoreversibility; poloxamer; carbopol; bioavailability
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Balakrishnan, P.; Park, E.-K.; Song, C.-K.; Ko, H.-J.; Hahn, T.-W.; Song, K.-W.; Cho, H.-J. Carbopol-Incorporated Thermoreversible Gel for Intranasal Drug Delivery. Molecules 2015, 20, 4124-4135.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top