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Molecules 2015, 20(2), 3190-3205; doi:10.3390/molecules20023190

Development of Bioorthogonal Reactions and Their Applications in Bioconjugation

Institute of Chemistry & BioMedical Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China
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Academic Editor: Scott Reed
Received: 5 January 2015 / Revised: 19 January 2015 / Accepted: 2 February 2015 / Published: 16 February 2015
(This article belongs to the Special Issue Bioconjugations)
View Full-Text   |   Download PDF [1053 KB, uploaded 16 February 2015]   |  

Abstract

Biomolecule labeling using chemical probes with specific biological activities has played important roles for the elucidation of complicated biological processes. Selective bioconjugation strategies are highly-demanded in the construction of various small-molecule probes to explore complex biological systems. Bioorthogonal reactions that undergo fast and selective ligation under bio-compatible conditions have found diverse applications in the development of new bioconjugation strategies. The development of new bioorthogonal reactions in the past decade has been summarized with comments on their potentials as bioconjugation method in the construction of various biological probes for investigating their target biomolecules. For the applications of bioorthogonal reactions in the site-selective biomolecule conjugation, examples have been presented on the bioconjugation of protein, glycan, nucleic acids and lipids. View Full-Text
Keywords: bioorthogonal reactions; bioconjugation strategies; biomolecules; chemical probes bioorthogonal reactions; bioconjugation strategies; biomolecules; chemical probes
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zheng, M.; Zheng, L.; Zhang, P.; Li, J.; Zhang, Y. Development of Bioorthogonal Reactions and Their Applications in Bioconjugation. Molecules 2015, 20, 3190-3205.

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