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Molecules 2015, 20(2), 3170-3189; doi:10.3390/molecules20023170

Synthesis and Antimicrobial Activity of N-Substituted-β-amino Acid Derivatives Containing 2-Hydroxyphenyl, Benzo[b]phenoxazine and Quinoxaline Moieties

1
Department of Physical and Inorganic Chemistry, Kaunas University of Technology, Kaunas 50254, Lithuania
2
Department of Organic Chemistry, Kaunas University of Technology, Kaunas 50254, Lithuania
3
Department of Technology of Biologically Active Substances, Pharmacy and Biotechnology, Lviv Politechnic National University, Lviv-13 79013, Ukraine
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 8 January 2015 / Revised: 4 February 2015 / Accepted: 4 February 2015 / Published: 13 February 2015
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [680 KB, uploaded 13 February 2015]   |  

Abstract

3-[(2-Hydroxyphenyl)amino]butanoic and 3-[(2-hydroxy-5-methyl(chloro)phenyl)amino]butanoic acids were converted to a series of derivatives containing hydrazide, pyrrole and chloroquinoxaline moieties. The corresponding benzo[b]phenoxazine derivatives were synthesized by the reaction of the obtained compounds with 2,3-dichloro-1,4-naphthoquinone. Five of the synthesized compounds exhibited good antimicrobial activity against Staphylococcus aureus and Mycobacterium luteum, whereas three compounds showed significant antifungal activity against Candida tenuis and Aspergillus niger. View Full-Text
Keywords: heterocycles; 1,4-naphthoquinone derivatives; hydrazones; antibacterial activity; fungicides heterocycles; 1,4-naphthoquinone derivatives; hydrazones; antibacterial activity; fungicides
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MDPI and ACS Style

Mickevičienė, K.; Baranauskaitė, R.; Kantminienė, K.; Stasevych, M.; Komarovska-Porokhnyavets, O.; Novikov, V. Synthesis and Antimicrobial Activity of N-Substituted-β-amino Acid Derivatives Containing 2-Hydroxyphenyl, Benzo[b]phenoxazine and Quinoxaline Moieties. Molecules 2015, 20, 3170-3189.

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