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Molecules 2015, 20(10), 19343-19360; doi:10.3390/molecules201019343

Analysis of the Photophysical Behavior and Rotational-Relaxation Dynamics of Coumarin 6 in Nonionic Micellar Environments: The Effect of Temperature

Department of Applied Physics II, Engineering School, University of Malaga, Malaga 29071, Spain
These authors contributed equally to this work.
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Academic Editor: Pascal Richomme
Received: 10 September 2015 / Revised: 8 October 2015 / Accepted: 16 October 2015 / Published: 23 October 2015
(This article belongs to the Special Issue Coumarins, Xanthones and Related Compounds)
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Abstract

The photodynamics of Coumarin 6 have been investigated in three nonionic micellar assemblies, i.e., n-dodecyl-β-d-maltoside (β-C12G2), p-tert-octyl-phenoxy polyethylene (9.5) ether (Triton X-100 or TX100) and n-dodecyl-hexaethylene-glycol (C12E6), to assess their potential use as encapsulation vehicles for hydrophobic drugs. To evaluate the effect of the micellar size and hydration, the study used a broad temperature range (293.15–323.15 K). The data presented here include steady-state absorption and emission spectra of the probe, dynamic light scattering, together with fluorescence lifetimes and both steady-state, as well as time-resolved fluorescence anisotropies. The time-resolved fluorescence anisotropy data were analyzed on the basis of the well-established two-step model. Our data reveal that the molecular probe in all of the cases is solubilized in the hydration layer of micelles, where it would sense a relatively polar environment. However, the probe was found to undergo a slower rotational reorientation when solubilized in the alkylpolyglycoside surfactant, as a result of a more compact microenvironment around the probe. The behavior of the parameters of the reorientation dynamics with temperature was analyzed on the basis of both micellar hydration and the head-group flexibility of the surfactants. View Full-Text
Keywords: Coumarin 6; n-dodecyl-β-d-maltoside; Triton X-100; n-dodecyl-hexaethylene-glycol; nonionic micellar assemblies; time-resolved fluorescence anisotropy Coumarin 6; n-dodecyl-β-d-maltoside; Triton X-100; n-dodecyl-hexaethylene-glycol; nonionic micellar assemblies; time-resolved fluorescence anisotropy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ruiz, C.C.; Hierrezuelo, J.M.; Molina-Bolivar, J.A. Analysis of the Photophysical Behavior and Rotational-Relaxation Dynamics of Coumarin 6 in Nonionic Micellar Environments: The Effect of Temperature. Molecules 2015, 20, 19343-19360.

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