Next Article in Journal
Extremely Randomized Machine Learning Methods for Compound Activity Prediction
Next Article in Special Issue
Auraptene Acts as an Anti-Inflammatory Agent in the Mouse Brain
Previous Article in Journal
Design, Synthesis and in Vivo Evaluation of Novel Glycosylated Sulfonylureas as Antihyperglycemic Agents
Previous Article in Special Issue
Analysis of the Photophysical Behavior and Rotational-Relaxation Dynamics of Coumarin 6 in Nonionic Micellar Environments: The Effect of Temperature
Article Menu

Export Article

Open AccessArticle
Molecules 2015, 20(11), 20079-20106; doi:10.3390/molecules201119677

Synergy and Other Interactions between Polymethoxyflavones from Citrus Byproducts

Allelopathy Group, Department of Organic Chemistry, Institute of Biomolecules (INBIO), Campus de Excelencia Internacional (ceiA3), Faculty of Science, University of Cadiz, C/República Saharaui n 7, 11510 Puerto Real, (Cádiz), Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Pascal Richomme
Received: 8 October 2015 / Revised: 28 October 2015 / Accepted: 29 October 2015 / Published: 6 November 2015
(This article belongs to the Special Issue Coumarins, Xanthones and Related Compounds)
View Full-Text   |   Download PDF [3152 KB, uploaded 6 November 2015]   |  

Abstract

The citrus by-products released from citrus processing plants may contain high levels of potentially bioactive compounds such as flavonoids, which are a widely distributed group of polyphenolic compounds with health-related properties based on their antioxidant activity. In the study reported here, the potential bioactivities and antioxidant activities of extracts, fractions and compounds from citrus by-products were evaluated along with the chemical interactions of binary mixtures of compounds and complex mixtures. The bioactivities and interactions were evaluated in wheat coleoptile bioassays and the antioxidant activity was evaluated by the al DPPH (2,2-diphenyl-1-picrylhdrazyl radical) radical scavenging assay. The extracts, fractions and most of the isolated compounds (mainly polymethoxyflavones) showed high activity in the wheat coleoptile bioassay. However, the antioxidant activity was not consistently high, except in the acetone extract fractions. Moreover, a study of the interactions with binary mixtures of polymethoxyflavones showed the occurrence of synergistic effects. The complex mixtures of fractions composed mainly of polymethoxyflavones caused a synergistic effect when it was added to a bioactive compound such as anethole. The results reported here highlight a new application for the wheat coleoptile bioassay as a quick tool to detect potential synergistic effects in compounds or mixtures. View Full-Text
Keywords: citrus by-products; flavonoids; synergism; isobolography; DPPH; coleoptiles citrus by-products; flavonoids; synergism; isobolography; DPPH; coleoptiles
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

García, B.F.; Torres, A.; Macías, F.A. Synergy and Other Interactions between Polymethoxyflavones from Citrus Byproducts. Molecules 2015, 20, 20079-20106.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top