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Molecules 2015, 20(10), 19330-19342; doi:10.3390/molecules201019330

Poly(Propylene Imine) Dendrimers and Amoxicillin as Dual-Action Antibacterial Agents

1
Department of Industrial Microbiology and Biotechnology, Faculty of Biology and Environmental Protection, University of Lodz, 12/16 Banacha Street, 90-237 Lodz, Poland
2
Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, 141/143, Pomorska Street, 90-236 Lodz, Poland
3
Leibniz Institute of Polymer Research Dresden, Hohe Street 6, 01069 Dresden, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Didier Astruc
Received: 25 September 2015 / Revised: 14 October 2015 / Accepted: 16 October 2015 / Published: 23 October 2015
(This article belongs to the Collection Nanomedicine)
View Full-Text   |   Download PDF [1275 KB, uploaded 23 October 2015]   |  

Abstract

Besides acting as antimicrobial compounds, dendrimers can be considered as agents that improve the therapeutic effectiveness of existing antibiotics. In this work we present a new approach to using amoxicillin (AMX) against reference strains of common Gram-negative pathogens, alone and in combination with poly(propylene imine) (PPI) dendrimers, or derivatives thereof, in which 100% of the available hydrogen atoms are substituted with maltose (PPI 100%malG3). The concentrations of dendrimers used remained in the range non-toxic to eukaryotic cells. The results indicate that PPI dendrimers significantly enhance the antibacterial effect of amoxicillin alone, allowing antibiotic doses to be reduced. It is important to reduce doses of amoxicillin because its widespread use in medicine could lead to the development of bacterial resistance and environmental pollution. This is the first report on the combined antibacterial activity of PPI surface-modified maltose dendrimers and amoxicillin. View Full-Text
Keywords: poly(propylene imine) dendrimers; antibacterial activity; amoxicillin poly(propylene imine) dendrimers; antibacterial activity; amoxicillin
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Wrońska, N.; Felczak, A.; Zawadzka, K.; Poszepczyńska, M.; Różalska, S.; Bryszewska, M.; Appelhans, D.; Lisowska, K. Poly(Propylene Imine) Dendrimers and Amoxicillin as Dual-Action Antibacterial Agents. Molecules 2015, 20, 19330-19342.

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