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Molecules 2015, 20(10), 17903-17912; doi:10.3390/molecules201017903

Activity of Polyphenolic Compounds against Candida glabrata

1
Departamento de Química Analítica, Facultad de Medicina, Universidad Autónoma de Nuevo León, Madero y Aguirre Pequeño, Col. Mitras Centro. Monterrey, N.L. C.P. 64460, Mexico
2
Departamento de Microbiología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Madero y Aguirre Pequeño, Col. Mitras Centro. Monterrey, N.L. C.P. 64460, Mexico
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 15 July 2015 / Revised: 16 September 2015 / Accepted: 24 September 2015 / Published: 29 September 2015
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [696 KB, uploaded 29 September 2015]

Abstract

Opportunistic mycoses increase the morbidity and mortality of immuno-compromised patients. Five Candida species have been shown to be responsible for 97% of worldwide cases of invasive candidiasis. Resistance of C. glabrata and C. krusei to azoles has been reported, and new, improved antifungal agents are needed. The current study was designed to evaluatethe activity of various polyphenolic compounds against Candida species. Antifungal activity was evaluated following the M27-A3 protocol of the Clinical and Laboratory Standards Institute, and antioxidant activity was determined using the DPPH assay. Myricetin and baicalein inhibited the growth of all species tested. This effect was strongest against C. glabrata, for which the minimum inhibitory concentration (MIC) value was lower than that of fluconazole. The MIC values against C. glabrata for myricitrin, luteolin, quercetin, 3-hydroxyflavone, and fisetin were similar to that of fluconazole. The antioxidant activity of all compounds was confirmed, and polyphenolic compounds with antioxidant activity had the greatest activity against C. glabrata. The structure and position of their hydroxyl groups appear to influence their activity against C. glabrata. View Full-Text
Keywords: Candida glabrata; polyphenols; flavonoids; myricetin; baicalein Candida glabrata; polyphenols; flavonoids; myricetin; baicalein
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Salazar-Aranda, R.; Granados-Guzmán, G.; Pérez-Meseguer, J.; González, G.M.; de Torres, N.W. Activity of Polyphenolic Compounds against Candida glabrata. Molecules 2015, 20, 17903-17912.

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