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Molecules 2015, 20(1), 974-986; doi:10.3390/molecules20010974

Antinociceptive Effect of Hydantoin 3-Phenyl-5-(4-ethylphenyl)-imidazolidine-2,4-dione in Mice

1
Center for Health Sciences, Federal University of Paraiba, João Pessoa PB 58059-900, Brazil
2
Department of Chemistry, Federal University of Paraiba, João Pessoa PB 58059-900, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 31 October 2014 / Accepted: 5 January 2015 / Published: 8 January 2015
(This article belongs to the Section Medicinal Chemistry)
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Abstract

Imidazolidine derivatives, or hydantoins, are synthetic compounds with different therapeutic applications. Many imidazolidine derivatives have psychopharmacological properties, such as phenytoin, famous for its anticonvulsant efficacy, but also effective in the treatment of neuropathic pain. The hydantoin, 3-phenyl-5-(4-ethylphenyl)-imidazolidine-2,4-dione (IM-3), synthesized from the amino acid, glycine, was selected for psychopharmacological studies in mice on the basis of its chemical and structural similarity with phenytoin. The first step of this study was to define the LD50, which determined the doses of 50, 100 and 200 mg/kg for subsequent tests. The results obtained from the behavioral screening indicated that IM-3 produces decreased ambulation and analgesia in mice. Motor coordination and anxiety behavior were not affected by treatment with IM-3, as observed in the rotarod and elevated plus-maze tests, respectively. Regarding its antinociceptive properties, IM-3 showed efficacy in the acetic acid-induced writhing test by increasing the latency of the first writhe and reducing the number of writhes, as well as reducing the paw licking time in the second phase of the formalin test. The behavior of treated animals exposed to the hot plate test, however, did not differ from that of the control group. These data suggest that IM-3 has antinociceptive effects in mice, which is probably mediated by anti-inflammatory mechanisms. View Full-Text
Keywords: hydantoin; psychopharmacology; antinociceptive; anti-inflammatory hydantoin; psychopharmacology; antinociceptive; anti-inflammatory
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

de Queiroz, R.B.; de Carvalho, F.L.; Fonsêca, D.V.; Barbosa-Filho, J.M.; Salgado, P.R.R.; Paulo, L.L.; de Queiroz, A.B.M.; Pordeus, L.C.M.; de Souza, S.A.; Souza, H.D.S.; Lira, B.F.; de Athayde-Filho, P.F. Antinociceptive Effect of Hydantoin 3-Phenyl-5-(4-ethylphenyl)-imidazolidine-2,4-dione in Mice. Molecules 2015, 20, 974-986.

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