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Molecules 2015, 20(1), 1571-1578; doi:10.3390/molecules20011571

Cytotoxic Activity and Composition of Petroleum Ether Extract from Magydaris tomentosa (Desf.) W. D. J. Koch (Apiaceae)

1
Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, Salerno 84084, Italy
2
Department of Pharmacy, University of Naples "Federico II", Via Domenico Montesano, Napoli 49 80131, Italy
3
Department STEBICEF, University of Palermo, Viale delle Scienze, Parco d'Orleans II, Palermo 90128, Italy
4
Laboratoire des Plantes Extremophiles—Biotechnologic Center Borj-CedriaTechnopark, B.P. 901, Hammam-Lif 2050, Tunisia
*
Author to whom correspondence should be addressed.
Academic Editor: Isabel C. F. R. Ferreira
Received: 30 October 2014 / Accepted: 9 January 2015 / Published: 16 January 2015
(This article belongs to the Collection Bioactive Compounds)
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Abstract

The petroleum ether extract of Magydaris tomentosa flowers (Desf.) W. D. J. Koch has been analyzed by GC-MS. It is mainly constituted by furanocoumarins such as xanthotoxin, xanthotoxol, isopimpinellin, and bergaptene. Other coumarins such as 7-methoxy-8-(2-formyl-2-methylpropyl) coumarin and osthole also occurred. The antiproliferative activity of Magydaris tomentosa flower extract has been evaluated in vitro on murine monocye/macrophages (J774A.1), human melanoma (A375) and human breast cancer (MCF-7) tumor cell lines, showing a major activity against the latter. View Full-Text
Keywords: Magydaris tomentosa; coumarins; furanocoumarins; xanthotoxin; xanthotoxol; isopimpinellin; osthole; bergaptene; MCF-7 Magydaris tomentosa; coumarins; furanocoumarins; xanthotoxin; xanthotoxol; isopimpinellin; osthole; bergaptene; MCF-7
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Autore, G.; Marzocco, S.; Formisano, C.; Bruno, M.; Rosselli, S.; Jemia, M.B.; Senatore, F. Cytotoxic Activity and Composition of Petroleum Ether Extract from Magydaris tomentosa (Desf.) W. D. J. Koch (Apiaceae). Molecules 2015, 20, 1571-1578.

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