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Molecules 2015, 20(1), 1210-1227; doi:10.3390/molecules20011210

Pro-Moieties of Antimicrobial Peptide Prodrugs

1
Department of Clinical Microbiology, Royal College of Surgeons in Ireland, Dublin 9, Ireland
2
Centre for Synthesis and Chemical Biology, Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland
*
Author to whom correspondence should be addressed.
Academic Editor: Jean Jacques Vanden Eynde
Received: 18 November 2014 / Accepted: 8 January 2015 / Published: 13 January 2015
(This article belongs to the Special Issue Prodrugs)
View Full-Text   |   Download PDF [852 KB, uploaded 13 January 2015]   |  

Abstract

Antimicrobial peptides (AMPs) are a promising class of antimicrobial agents that have been garnering increasing attention as resistance renders many conventional antibiotics ineffective. Extensive research has resulted in a large library of highly-active AMPs. However, several issues serve as an impediment to their clinical development, not least the issue of host toxicity. An approach that may allow otherwise cytotoxic AMPs to be used is to deliver them as a prodrug, targeting antimicrobial activity and limiting toxic effects on the host. The varied library of AMPs is complemented by a selection of different possible pro-moieties, each with their own characteristics. This review deals with the different pro-moieties that have been used with AMPs and discusses the merits of each. View Full-Text
Keywords: antimicrobial; peptides; PEG; prodrug; antibody; charge antimicrobial; peptides; PEG; prodrug; antibody; charge
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Forde, E.; Devocelle, M. Pro-Moieties of Antimicrobial Peptide Prodrugs. Molecules 2015, 20, 1210-1227.

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