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Molecules 2015, 20(4), 7292-7308; doi:10.3390/molecules20047292

Evaluation of Novel Antibacterial N-Halamine Nanoparticles Prodrugs towards Susceptibility of Escherichia coli Induced by DksA Protein

1
College of Life Science, Inner Mongolia University, Hohhot 010021, China
2
College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Jean Jacques Vanden Eynde
Received: 12 March 2015 / Revised: 3 April 2015 / Accepted: 7 April 2015 / Published: 21 April 2015
(This article belongs to the Special Issue Prodrugs)
View Full-Text   |   Download PDF [3664 KB, uploaded 21 April 2015]   |  

Abstract

Novel N-halamine nanoparticles potentially useful for killing pathogenic bacteria, i.e., SiO2@PS/N-halamine NPs, were successfully synthesized via the immobilization of N-halamines onto the polystyrene-coated silica nanoparticles (SiO2@PS NPs). The effect of reaction conditions, i.e., chlorination temperature, bleaching concentration, chlorination time, on the oxidative chlorine content in the products was systematically investigated. The antibacterial activity of the products was tested via the modified plate counting methd using Escherichia coli (E. coli) as a model bacterium. The possible mechanism of the antibacterial action of the products was also studied using scanning electron microscopy combined with a inhibition zone study. The antimicrobial capability of the products was well controlled by tuning the oxidative chlorine content in the products. More importantly, the role of DksA protein in the susceptibility of E. coli against the products was proven using a time-kill assay. This in-depth investigation of the sensitivity of E. coli towards N-halamine NPs provides a systematic understanding of the utility of N-halamines for deactivating bacteria or even disease control. View Full-Text
Keywords: N-halamine; silica; polystyrene; nanoparticles; antibacterial; DksA protein; E. coli N-halamine; silica; polystyrene; nanoparticles; antibacterial; DksA protein; E. coli
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Dong, Q.; Dong, A.; Morigen. Evaluation of Novel Antibacterial N-Halamine Nanoparticles Prodrugs towards Susceptibility of Escherichia coli Induced by DksA Protein. Molecules 2015, 20, 7292-7308.

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