Next Issue
Previous Issue

E-Mail Alert

Add your e-mail address to receive forthcoming issues of this journal:

Journal Browser

Journal Browser

Table of Contents

Molecules, Volume 2, Issue 4 (April 1997), Pages 62-79, Articles M1-M9

  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list.
  • You may sign up for e-mail alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Readerexternal link to open them.
View options order results:
result details:
Displaying articles 1-11
Export citation of selected articles as:

Research

Jump to: Other

Open AccessArticle o-Nitroaryl-bis(5-methylfur-2-yl)methanes as Versatile Synthons for the Synthesis of Nitrogen-Containing Heterocycles
Molecules 1997, 2(4), 62-68; doi:10.3390/20400062
Received: 25 October 1996 / Accepted: 17 January 1997 / Published: 10 April 1997
Cited by 15 | PDF Full-text (38 KB)
Abstract
2-Nitroaryldifurylmethanes 1a and 1b, readily available by condensation of 2-nitrobenzaldehyde and 6-nitroveratraldehyde with 2-methylfuran, were transformed into indole, cinnoline and benzothiazine-3,1 derivatives. The reduction of 2-nitroaryldifurylmethanes gave the corresponding anilines 2a,b or indole 3 depending on the reaction conditions. A plausible mechanism [...] Read more.
2-Nitroaryldifurylmethanes 1a and 1b, readily available by condensation of 2-nitrobenzaldehyde and 6-nitroveratraldehyde with 2-methylfuran, were transformed into indole, cinnoline and benzothiazine-3,1 derivatives. The reduction of 2-nitroaryldifurylmethanes gave the corresponding anilines 2a,b or indole 3 depending on the reaction conditions. A plausible mechanism for the last reaction involving intramolecular heterocyclic addition between a nitroso-group and a furan ring is proposed. Diazotisation of the amine 2b gave a cinnoline derivative - a product of intramolecular oxidative furan ring opening. Treatment of isothiocyanates 7a,b with perchloric acid resulted in a new rearrangement with furan ring migration leading to the 4-Hbenzothiazine-3,1 derivatives. Full article
Open AccessArticle Synthesis and Reactions of Furo[2,3-b]pyrroles
Molecules 1997, 2(4), 69-79; doi:10.3390/20400069
Received: 27 December 1996 / Accepted: 24 January 1997 / Published: 20 April 1997
Cited by 7 | PDF Full-text (48 KB)
Abstract
Methyl 6H-furo[2,3-b]pyrrole-5-carboxylate (2a) was prepared by thermolysis of the corresponding methyl 2-azido-3-(3-furyl)propenoate (1). 6-Methyl (2b) and 6-benzyl (2c) derivatives were obtained using phase-transfer catalysis conditions (PTC). The formylation of 2a-2c gave 2-formylated compounds (3a-3c). Compounds 4b, 4c were prepared by [...] Read more.
Methyl 6H-furo[2,3-b]pyrrole-5-carboxylate (2a) was prepared by thermolysis of the corresponding methyl 2-azido-3-(3-furyl)propenoate (1). 6-Methyl (2b) and 6-benzyl (2c) derivatives were obtained using phase-transfer catalysis conditions (PTC). The formylation of 2a-2c gave 2-formylated compounds (3a-3c). Compounds 4b, 4c were prepared by reactions of corresponding esters 2b, 2c with hydrazine in refluxing ethanol. By reaction of 3a-3c with hydroxylammonium chloride in acetic anhydride in the presence of pyridine, methyl 2-cyano-6-R1-furo[2,3-b]pyrrole-5-carboxylates (5a-5c) were obtained. The reaction of these compounds with sodium azide and ammonium chloride in dimethylformamide led to methyl 2-(5'-tetrazolyl)-6-R1-furo[2,3-b]pyrrole-5-carboxylates (6a-6c). A series of 5-methoxycarbonyl-6-R1-furo[2,3-b]pyrrole-2-carbaldehyde N,N-dimethylhydrazones (7a-7c) was prepared from methyl 2-formyl-6-R1-furo[2,3-b]pyrrole-5-carboxylates (3a-3c) and unsym-dimethylhydrazine. The correlation of the 13C and 15N chemical shifts with the data of the calculated (AM1) net atomic charges is discussed. Full article

Other

Jump to: Research

Open AccessShort Note 1,3-Di(4-benzyloxybenzoyl)indole
Molecules 1997, 2(4), M1; doi:10.3390/M1
Received: 15 January 1997 / Published: 15 April 1997
PDF Full-text (80 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note N,N'-bis[(3,4-Dichlorophenyl)methyl]ethanediamide
Molecules 1997, 2(4), M3; doi:10.3390/M3
Received: 15 January 1997 / Published: 15 April 1997
PDF Full-text (83 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note N-(3,4-Dichlorophenyl)methyl Oxamic Acid
Molecules 1997, 2(4), M4; doi:10.3390/M4
Received: 15 January 1997 / Published: 15 April 1997
PDF Full-text (82 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note 1-Ethyl 4-(2-methoxyethyl) 2-(1,2,3,4-Tetrahydro-1,3-dimethyl-2,4-dioxopyrimidin-5-yl)butanedioate
Molecules 1997, 2(4), M5; doi:10.3390/M5
Received: 1 February 1997 / Published: 15 April 1997
PDF Full-text (81 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note 1-Ethyl 4-propyl 2-(1,2,3,4-Tetrahydro-1,3-dimethyl-2,4-dioxopyrimidin-5-yl)butanedioate
Molecules 1997, 2(4), M6; doi:10.3390/M6
Received: 1 February 1997 / Published: 15 April 1997
PDF Full-text (81 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note 1-Ethyl 4-(1-methylethyl) 2-(1,2,3,4-Tetrahydro-1,3-dimethyl-2,4-dioxopyrimidin-5-yl)butanedioate
Molecules 1997, 2(4), M7; doi:10.3390/M7
Received: 1 February 1997 / Published: 15 April 1997
PDF Full-text (81 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note 1-Ethyl 4-(1,1-dimethylethyl) 2-(1,2,3,4-Tetrahydro-1,3-dimethyl-2,4-dioxopyrimidin-5-yl)butanedioate
Molecules 1997, 2(4), M8; doi:10.3390/M8
Received: 1 February 1997 / Published: 15 April 1997
PDF Full-text (81 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note 1-Ethyl 4-(2-oxopropyl) 2-(1,2,3,4-Tetrahydro-1,3-dimethyl-2,4-dioxopyrimidin-5-yl)butanedioate
Molecules 1997, 2(4), M9; doi:10.3390/M9
Received: 1 February 1997 / Published: 15 April 1997
PDF Full-text (81 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note Propyl 3-(1,2,3,4-Tetrahydro-1,3,6-trimethyl-2,4-dioxopyrimidin-5-yl)butanoate
Molecules 1997, 2(4), M10; doi:10.3390/M10
Received: 1 February 1997 / Published: 15 April 1997
PDF Full-text (81 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

Journal Contact

MDPI AG
Molecules Editorial Office
St. Alban-Anlage 66, 4052 Basel, Switzerland
molecules@mdpi.com
Tel. +41 61 683 77 34
Fax: +41 61 302 89 18
Editorial Board
Contact Details Submit to Molecules
Back to Top