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Molecules 2014, 19(9), 14999-15004; doi:10.3390/molecules190914999

A Novel Synthesis of the Oxazolidinone Antithrombotic Agent Rivaroxaban

Pharmacy College, Chongqing Medical University, Chongqing 400016, China
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Received: 26 June 2014 / Revised: 9 September 2014 / Accepted: 9 September 2014 / Published: 18 September 2014
(This article belongs to the Section Organic Synthesis)
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Abstract

A facile synthetic route of rivaroxaban has been developed. Using commercially available (R)-epichlorohydrin and bromobenzene as the starting materials, rivaroxaban was obtained in 39% overall yield using a Goldberg coupling as the key step. The synthetic route represents a convenient procedure for the production of rivaroxaban. View Full-Text
Keywords: rivaroxaban; oxazolidinone; Goldberg coupling reaction rivaroxaban; oxazolidinone; Goldberg coupling reaction
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MDPI and ACS Style

Yuan, J.; Liu, K.; Li, L.; Yuan, Y.; Liu, X.; Li, Y. A Novel Synthesis of the Oxazolidinone Antithrombotic Agent Rivaroxaban. Molecules 2014, 19, 14999-15004.

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