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Molecules 2014, 19(9), 14987-14998; doi:10.3390/molecules190914987

Synthesis of New Quinoxalines Containing an Oxirane Ring by the TDAE Strategy and in Vitro Evaluation in Neuroblastoma Cell Lines

1
Aix-Marseille Université, CNRS, Institut de Chimie Radicalaire ICR, UMR 7273, Laboratoire de Pharmaco-Chimie Radicalaire, Marseille 13385, France
2
Aix-Marseille Université, INSERM, CRO2, UMR_S911, Marseille 13385, France
3
AP-HM, Hôpital Timone, Pharmacie, Marseille 13005, France
*
Author to whom correspondence should be addressed.
Received: 25 July 2014 / Revised: 9 September 2014 / Accepted: 11 September 2014 / Published: 18 September 2014
(This article belongs to the Section Medicinal Chemistry)
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Abstract

Neuroblastoma is an aggressive pediatric malignancy with significant chemotherapeutic resistance. In order to obtain new compounds active on neuroblastoma cell lines, we investigated the reactivity of carbanion formed via TDAE in quinoxaline series. The new synthesized compounds were tested for their anti-proliferative activity on two neuroblastoma cell lines, and seven oxirane derivatives obtained interesting activities. View Full-Text
Keywords: quinoxaline; TDAE; XK469; isatin; oxirane; neuroblastoma; anti-cancer drugs quinoxaline; TDAE; XK469; isatin; oxirane; neuroblastoma; anti-cancer drugs
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MDPI and ACS Style

Montana, M.; Correard, F.; Khoumeri, O.; Esteve, M.-A.; Terme, T.; Vanelle, P. Synthesis of New Quinoxalines Containing an Oxirane Ring by the TDAE Strategy and in Vitro Evaluation in Neuroblastoma Cell Lines. Molecules 2014, 19, 14987-14998.

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