Next Article in Journal
Graphene-Based Nanomaterials as Heterogeneous Acid Catalysts: A Comprehensive Perspective
Previous Article in Journal
Preparation of Calcium- and Magnesium-Fortified Potato Starches with Altered Pasting Properties
Article Menu

Export Article

Open AccessArticle
Molecules 2014, 19(9), 14567-14581; doi:10.3390/molecules190914567

Evaluation of the Antioxidant, Anti-Inflammatory, and Anticancer Activities of Euphorbia hirta Ethanolic Extract

1
Department of Animal Biotechnology, Faculty of Biotechnology, Jeju National University, Jeju 690-756, Korea
2
Department of Marine Life Science, Jeju National University, Jeju 690-756, Korea
3
Faculty of Biotechnology, School of Applied Life Science, Jeju National University, Jeju 690-756, Korea
4
BRM Institute, Seoul 135-010, Korea
5
Department of Animal Biotechnology, School of Animal Life Sciences, Kangwon National University, Chuncheon 200-701, Korea
6
Department of Oral Biochemistry, Dental Science Research Institute, Chonnam National University, Gwangju 500-757, Korea
*
Author to whom correspondence should be addressed.
Received: 9 August 2014 / Accepted: 4 September 2014 / Published: 15 September 2014
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [1458 KB, uploaded 15 September 2014]   |  

Abstract

This study evaluated the chemical composition, antioxidant, anti-inflammatory and anticancer activities of a Euphorbia hirta L. extract. The antioxidant activities of whole E. hirta ethanol extract were determined by electron spin resonance spectrophotometric analysis of 1,1-diphenyl-2-picryl-hydrazyl (DPPH), hydroxyl, and alkyl radical levels and by using an online high-performance liquid chromatography (HPLC)-2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) assay. The E. hirta ethanol extract (0.5 mg/mL) exhibited DPPH-scavenging activity of 61.19% ± 0.22%, while the positive control (0.5 mg/mL ascorbic acid) had 100% ± 0.22% activity. The concentration of the extract required to trap 50% of DPPH (IC50) was 0.205 mg/mL. Online HPLC analysis of the extract also showed strong antioxidant activity. The anti-inflammatory activity of the E. hirta extract was assessed in lipopolysaccharide-induced RAW 264.7 macrophages. The anti-inflammatory activity was highest in the presence of 200 µg/mL E. hirta extract, and nitric oxide production was decreased significantly (p < 0.05). The extract also showed selective anticancer activity at a concentration of 100 µg/mL (p < 0.05). These results indicated that E. hirta may warrant further investigation for the development of antioxidant, anti-inflammatory, and anticancer herbal medications. View Full-Text
Keywords: Euphorbia hirta; chemical composition; online HPLC-ABTS+• bioassay; antioxidant; anti-inflammatory; anticancer Euphorbia hirta; chemical composition; online HPLC-ABTS+• bioassay; antioxidant; anti-inflammatory; anticancer
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Sharma, N.; Samarakoon, K.W.; Gyawali, R.; Park, Y.-H.; Lee, S.-J.; Oh, S.J.; Lee, T.-H.; Jeong, D.K. Evaluation of the Antioxidant, Anti-Inflammatory, and Anticancer Activities of Euphorbia hirta Ethanolic Extract. Molecules 2014, 19, 14567-14581.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top