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Molecules 2014, 19(9), 14195-14203; https://doi.org/10.3390/molecules190914195

Cytotoxic Illudalane Sesquiterpenes from the Wood-Decay Fungus Granulobasidium vellereum (Ellis & Cragin) Jülich

1
Department of Chemistry and Biotechnology, Uppsala BioCenter, Swedish University of Agricultural Sciences, P.O. Box 7015, Uppsala SE-750 07, Sweden
2
Department of Forest Mycology and Plant Pathology, Uppsala BioCenter, Swedish University of Agricultural Sciences, P.O. Box 7026, Uppsala SE-750 07, Sweden
*
Author to whom correspondence should be addressed.
Received: 6 August 2014 / Revised: 28 August 2014 / Accepted: 4 September 2014 / Published: 9 September 2014
(This article belongs to the Section Natural Products Chemistry)
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Abstract

Seven illudalane sesquiterpenes were obtained from the wood decomposing fungus Granulobasidium vellereum: granuloinden A, granuloinden B and dihydrogranuloinden, along with the previously known compounds radulactone, pterosin M, echinolactone A and D. Granuloinden B showed potent cytotoxic activity against the Huh7 and MT4 tumor cell lines (CC50 values of 6.7 and 0.15 µM, respectively), whereas granuloinden A and dihydrogranuloinden had no or moderate activity. View Full-Text
Keywords: Granulobasidium vellereum; sesquiterpenes; illudalane; cytotoxic Granulobasidium vellereum; sesquiterpenes; illudalane; cytotoxic
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Nord, C.L.; Menkis, A.; Broberg, A. Cytotoxic Illudalane Sesquiterpenes from the Wood-Decay Fungus Granulobasidium vellereum (Ellis & Cragin) Jülich. Molecules 2014, 19, 14195-14203.

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