Next Article in Journal
Protoberberine Isoquinoline Alkaloids from Arcangelisia gusanlung
Previous Article in Journal
Self-Assembled Nanoparticles of Glycyrrhetic Acid-Modified Pullulan as a Novel Carrier of Curcumin
Article Menu

Export Article

Open AccessArticle
Molecules 2014, 19(9), 13319-13331; doi:10.3390/molecules190913319

Cyclic Peptide-Capped Gold Nanoparticles for Enhanced siRNA Delivery

School of Pharmacy, Chapman University, Irvine, CA 92618, USA
Department of Cell and Molecular Biology, University of Rhode Island, Kingston, RI 02881, USA
Author to whom correspondence should be addressed.
Received: 9 June 2014 / Revised: 22 August 2014 / Accepted: 22 August 2014 / Published: 28 August 2014
(This article belongs to the Special Issue Delivery Systems of Anticancer Agents)
View Full-Text   |   Download PDF [1061 KB, uploaded 1 September 2014]   |  


Previously, we have reported the synthesis of a homochiral l-cyclic peptide [WR]5 and its use for delivery of anti-HIV drugs and biomolecules. A physical mixture of HAuCl4 and the peptide generated peptide-capped gold nanoparticles. Here, [WR]5 and [WR]5-AuNPs were tested for their efficiency to deliver a small interfering RNA molecule (siRNA) in human cervix adenocarcinoma (HeLa) cells. Flow cytometry investigation revealed that the intracellular uptake of a fluorescence-labeled non-targeting siRNA (200 nM) was enhanced in the presence of [WR]5 and [WR]5-AuNPs by 2- and 3.8-fold when compared with that of siRNA alone after 24 h incubation. Comparative toxicity results showed that [WR]5 and [WR]5-AuNPs were less toxic in cells compared to other available carrier systems, such as Lipofectamine. View Full-Text
Keywords: small interfering RNA (siRNA) delivery; gold nanoparticles; cyclic peptides; siRNA delivery systems (DDS) small interfering RNA (siRNA) delivery; gold nanoparticles; cyclic peptides; siRNA delivery systems (DDS)

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Shirazi, A.N.; Paquin, K.L.; Howlett, N.G.; Mandal, D.; Parang, K. Cyclic Peptide-Capped Gold Nanoparticles for Enhanced siRNA Delivery. Molecules 2014, 19, 13319-13331.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top