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Molecules 2014, 19(9), 13319-13331; doi:10.3390/molecules190913319

Cyclic Peptide-Capped Gold Nanoparticles for Enhanced siRNA Delivery

1
School of Pharmacy, Chapman University, Irvine, CA 92618, USA
2
Department of Cell and Molecular Biology, University of Rhode Island, Kingston, RI 02881, USA
*
Author to whom correspondence should be addressed.
Received: 9 June 2014 / Revised: 22 August 2014 / Accepted: 22 August 2014 / Published: 28 August 2014
(This article belongs to the Special Issue Delivery Systems of Anticancer Agents)
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Abstract

Previously, we have reported the synthesis of a homochiral l-cyclic peptide [WR]5 and its use for delivery of anti-HIV drugs and biomolecules. A physical mixture of HAuCl4 and the peptide generated peptide-capped gold nanoparticles. Here, [WR]5 and [WR]5-AuNPs were tested for their efficiency to deliver a small interfering RNA molecule (siRNA) in human cervix adenocarcinoma (HeLa) cells. Flow cytometry investigation revealed that the intracellular uptake of a fluorescence-labeled non-targeting siRNA (200 nM) was enhanced in the presence of [WR]5 and [WR]5-AuNPs by 2- and 3.8-fold when compared with that of siRNA alone after 24 h incubation. Comparative toxicity results showed that [WR]5 and [WR]5-AuNPs were less toxic in cells compared to other available carrier systems, such as Lipofectamine. View Full-Text
Keywords: small interfering RNA (siRNA) delivery; gold nanoparticles; cyclic peptides; siRNA delivery systems (DDS) small interfering RNA (siRNA) delivery; gold nanoparticles; cyclic peptides; siRNA delivery systems (DDS)
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MDPI and ACS Style

Shirazi, A.N.; Paquin, K.L.; Howlett, N.G.; Mandal, D.; Parang, K. Cyclic Peptide-Capped Gold Nanoparticles for Enhanced siRNA Delivery. Molecules 2014, 19, 13319-13331.

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