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Molecules 2014, 19(9), 13332-13341; doi:10.3390/molecules190913332

Protoberberine Isoquinoline Alkaloids from Arcangelisia gusanlung

1
Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100193, China
2
School of Medicine, China Three Gorges University, Yichang 443002, China
3
Hainan Branch of the Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Wanning 571533, China
4
China Hubei Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Science, China Three Gorges University, Yichang 443002, China
*
Author to whom correspondence should be addressed.
Received: 25 July 2014 / Revised: 20 August 2014 / Accepted: 21 August 2014 / Published: 29 August 2014
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [730 KB, uploaded 29 August 2014]   |  

Abstract

HPLC-DAD-directed isolation and purification of the methanol extract of stems of Arcangelisia gusanlung H. S. Lo. led to the isolation of a new protoberberine alkaloid, gusanlung E (1), along with fourteen known derivatives 215, seven of which were obtained from the genus Arcangelisia for the first time. The structures and absolute stereochemistry of these compounds were elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR, mass spectrometry, and CD analyses. Gusanlung E (1) expressed weak cytotoxic activity against the SGC 7901 cell line with an IC50 value of 85.1 µM. View Full-Text
Keywords: protoberberine alkaloid; Arcangelisia gusanlung; gusanlung E protoberberine alkaloid; Arcangelisia gusanlung; gusanlung E
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MDPI and ACS Style

Yu, L.-L.; Li, R.-T.; Ai, Y.-B.; Liu, W.; Deng, Z.-S.; Zou, Z.-M. Protoberberine Isoquinoline Alkaloids from Arcangelisia gusanlung. Molecules 2014, 19, 13332-13341.

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