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Molecules 2014, 19(9), 13305-13318; doi:10.3390/molecules190913305

Self-Assembled Nanoparticles of Glycyrrhetic Acid-Modified Pullulan as a Novel Carrier of Curcumin

1
Department of Pharmacology, Shantou University Medical College, Shantou 515041, China
2
Department of Pharmacy, First Affiliated Hospital, Shantou University Medical College, Shantou 515041, China
3
Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
4
Medical College, Hunan Normal University, Changsha 410013, China
5
Chinese Academy of Sciences, Shantou Marine Plants Experiment Station, Shantou 515041, China
6
Traditional Chinese Medicine Laboratory, Shantou University Medical College, Shantou 515041, China
7
Department of Cardiovascular Diseases, First Affiliated Hospital, Shantou University Medical College, Shantou 515041, China
*
Authors to whom correspondence should be addressed.
Received: 18 June 2014 / Revised: 22 August 2014 / Accepted: 25 August 2014 / Published: 28 August 2014
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [2104 KB, uploaded 28 August 2014]   |  

Abstract

Glycyrrhetic acid (GA)-modified pullulan nanoparticles (GAP NPs) were synthesized as a novel carrier of curcumin (CUR) with a degree of substitution (DS) of GA moieties within the range of 1.2–6.2 groups per hundred glucose units. In the present study, we investigated the physicochemical characteristics, release behavior, in vitro cytotoxicity and cellular uptake of the particles. Self-assembled GAP NPs with spherical shapes could readily improve the water solubility and stability of CUR. The CUR release was sustained and pH-dependent. The cellular uptake of CUR-GAP NPs was confirmed by green fluorescence in the cells. An MTT study showed CUR-GAP NPs with higher cytotoxicity in HepG2 cells than free CUR, but GAP NPs had no significant cytotoxicity. GAP is thus an excellent carrier for the solubilization, stabilization, and controlled delivery of CUR. View Full-Text
Keywords: pullulan; glycyrrhetic acid; self-aggregated nanoparticle; curcumin; drug delivery pullulan; glycyrrhetic acid; self-aggregated nanoparticle; curcumin; drug delivery
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Yuan, R.; Zheng, F.; Zhong, S.; Tao, X.; Zhang, Y.; Gao, F.; Yao, F.; Chen, J.; Chen, Y.; Shi, G. Self-Assembled Nanoparticles of Glycyrrhetic Acid-Modified Pullulan as a Novel Carrier of Curcumin. Molecules 2014, 19, 13305-13318.

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