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Molecules 2014, 19(8), 12320-12327; doi:10.3390/molecules190812320

Rumphellaones B and C, New 4,5-Seco-Caryophyllane Sesquiterpenoids from Rumphella

1
Department of Applied Chemistry, National Pingtung University, Pingtung 900, Taiwan
2
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
3
Department of Marine Biotechnology and Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
4
Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
5
Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan
6
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
7
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
8
Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan
9
Institute of Marine Biology, Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
10
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 14 July 2014 / Revised: 11 August 2014 / Accepted: 11 August 2014 / Published: 14 August 2014
(This article belongs to the Section Natural Products)
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Abstract

Two new 4,5-seco-caryophyllane sesquiterpenoids, rumphellaones B (1) and C (2), which were found to possess unprecedented γ-lactone moieties, were obtained from the gorgonian coral Rumphella antipathies. The structures of 1 and 2 were elucidated by spectroscopic methods and compound 2 was found to display modest inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils at a concentration of 10 μg/mL View Full-Text
Keywords: Rumphella antipathies; rumphellaones B and C; caryophyllane-type sesquiterpenoid; anti-inflammatory activity Rumphella antipathies; rumphellaones B and C; caryophyllane-type sesquiterpenoid; anti-inflammatory activity
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MDPI and ACS Style

Chung, H.-M.; Wang, W.-H.; Hwang, T.-L.; Li, J.-J.; Fang, L.-S.; Wu, Y.-C.; Sung, P.-J. Rumphellaones B and C, New 4,5-Seco-Caryophyllane Sesquiterpenoids from Rumphella . Molecules 2014, 19, 12320-12327.

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