Rumphellaones B and C, New 4,5-Seco-Caryophyllane Sesquiterpenoids from Rumphella
Department of Applied Chemistry, National Pingtung University, Pingtung 900, Taiwan
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Department of Marine Biotechnology and Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan
Institute of Marine Biology, Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Received: 14 July 2014 / Revised: 11 August 2014 / Accepted: 11 August 2014 / Published: 14 August 2014
Two new 4,5-seco
-caryophyllane sesquiterpenoids, rumphellaones B (1
) and C (2
), which were found to possess unprecedented γ-lactone moieties, were obtained from the gorgonian coral Rumphella antipathies
. The structures of 1
were elucidated by spectroscopic methods and compound 2
was found to display modest inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils at a concentration of 10 μg/mL
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Chung, H.-M.; Wang, W.-H.; Hwang, T.-L.; Li, J.-J.; Fang, L.-S.; Wu, Y.-C.; Sung, P.-J. Rumphellaones B and C, New 4,5-Seco-Caryophyllane Sesquiterpenoids from Rumphella . Molecules 2014, 19, 12320-12327.
Chung H-M, Wang W-H, Hwang T-L, Li J-J, Fang L-S, Wu Y-C, Sung P-J. Rumphellaones B and C, New 4,5-Seco-Caryophyllane Sesquiterpenoids from Rumphella . Molecules. 2014; 19(8):12320-12327.
Chung, Hsu-Ming; Wang, Wei-Hsien; Hwang, Tsong-Long; Li, Jan-Jung; Fang, Lee-Shing; Wu, Yang-Chang; Sung, Ping-Jyun. 2014. "Rumphellaones B and C, New 4,5-Seco-Caryophyllane Sesquiterpenoids from Rumphella ." Molecules 19, no. 8: 12320-12327.
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