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Molecules 2014, 19(8), 11933-11987; doi:10.3390/molecules190811933

Ruthenium Polypyridine Complexes Combined with Oligonucleotides for Bioanalysis: A Review

Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing University, Nanjing 210093, China
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Received: 15 May 2014 / Revised: 17 July 2014 / Accepted: 28 July 2014 / Published: 11 August 2014
(This article belongs to the Special Issue Practical Applications of Metal Complexes)

Abstract

Ruthenium complexes are among the most interesting coordination complexes and they have attracted great attention over the past decades due to their appealing biological, catalytic, electronic and optical properties. Ruthenium complexes have found a unique niche in bioanalysis, as demonstrated by the substantial progress made in the field. In this review, the applications of ruthenium complexes coordinated with polypyridine ligands (and analogues) in bioanalysis are discussed. Three main detection methods based on electrochemistry, electrochemiluminescence, and photoluminscence are covered. The important targets, including DNA and other biologically important targets, are detected by specific biorecognition with the corresponding oligonucleotides as the biorecognition elements (i.e., DNA is probed by its complementary strand and other targets are detected by functional nucleic acids, respectively). Selected examples are provided and thoroughly discussed to highlight the substantial progress made so far. Finally, a brief summary with perspectives is included. View Full-Text
Keywords: aptamer; bioanalysis; DNA detection; DNAzyme; electrochemiluminescence; electrochemistry; functional nanomaterials; ruthenium complexes aptamer; bioanalysis; DNA detection; DNAzyme; electrochemiluminescence; electrochemistry; functional nanomaterials; ruthenium complexes
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Zhang, S.; Ding, Y.; Wei, H. Ruthenium Polypyridine Complexes Combined with Oligonucleotides for Bioanalysis: A Review. Molecules 2014, 19, 11933-11987.

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