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Molecules 2014, 19(8), 11572-11585; doi:10.3390/molecules190811572
Article

Synthesis and in Vitro Antimicrobial Evaluation of New N-Heterocyclic Diquaternary Pyridinium Compounds

1
, 2
, 2
, 1,* , 2
 and 3,4
1 Department of Chemistry, Physics and Environment, Faculty of Science and Environment, "Dunarea de Jos" University of Galati, 111 Domneasca Street, 800201 Galati, Romania 2 Department of Food Science, Food Engineering and Applied Biotechnology, Faculty of Food Science and Engineering, "Dunarea de Jos" University of Galati, 111 Domneasca Street, 800201 Galati, Romania 3 Centre National de la Recherche Scientifique (CNRS), UMR 5063, Department of Molecular Pharmacochemistry, F-38041 Grenoble, France 4 Department of Molecular Pharmacochemistry, University of Grenoble-Alpes, F-38041 Grenoble, France
* Author to whom correspondence should be addressed.
Received: 11 May 2014 / Revised: 25 July 2014 / Accepted: 28 July 2014 / Published: 5 August 2014
(This article belongs to the Special Issue Heterocyclic and Medicinal Chemistry)
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Abstract

A series of bis-pyridinium quaternary ammonium salts (bis-PyQAs) with different aryl and heteroaryl moieties were synthesized and their antimicrobial activity investigated. The inhibition effect of the compounds was evaluated against bacteria, molds and yeasts; the activities were expressed as the minimum inhibitory concentrations (MIC). The relationships between the structure descriptors (logP, polarizability, polar surface area (2D), van der Waals area (3D)) and the biological activity of the tested bis-PyQAs are discussed.
Keywords: pyridinium quaternary salts; antimicrobial activity; 4-[2-(pyridin-4-yl)ethyl]pyridine, 4,4'-bipyridine pyridinium quaternary salts; antimicrobial activity; 4-[2-(pyridin-4-yl)ethyl]pyridine, 4,4'-bipyridine
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Furdui, B.; Parfene, G.; Ghinea, I.O.; Dinica, R.M.; Bahrim, G.; Demeunynck, M. Synthesis and in Vitro Antimicrobial Evaluation of New N-Heterocyclic Diquaternary Pyridinium Compounds. Molecules 2014, 19, 11572-11585.

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