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Molecules 2014, 19(8), 11572-11585; doi:10.3390/molecules190811572
Article

Synthesis and in Vitro Antimicrobial Evaluation of New N-Heterocyclic Diquaternary Pyridinium Compounds

1
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 and 3,4
Received: 11 May 2014; in revised form: 25 July 2014 / Accepted: 28 July 2014 / Published: 5 August 2014
(This article belongs to the Special Issue Heterocyclic and Medicinal Chemistry)
View Full-Text   |   Download PDF [777 KB, uploaded 5 August 2014]   |   Browse Figures
Abstract: A series of bis-pyridinium quaternary ammonium salts (bis-PyQAs) with different aryl and heteroaryl moieties were synthesized and their antimicrobial activity investigated. The inhibition effect of the compounds was evaluated against bacteria, molds and yeasts; the activities were expressed as the minimum inhibitory concentrations (MIC). The relationships between the structure descriptors (logP, polarizability, polar surface area (2D), van der Waals area (3D)) and the biological activity of the tested bis-PyQAs are discussed.
Keywords: pyridinium quaternary salts; antimicrobial activity; 4-[2-(pyridin-4-yl)ethyl]pyridine, 4,4'-bipyridine pyridinium quaternary salts; antimicrobial activity; 4-[2-(pyridin-4-yl)ethyl]pyridine, 4,4'-bipyridine
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Furdui, B.; Parfene, G.; Ghinea, I.O.; Dinica, R.M.; Bahrim, G.; Demeunynck, M. Synthesis and in Vitro Antimicrobial Evaluation of New N-Heterocyclic Diquaternary Pyridinium Compounds. Molecules 2014, 19, 11572-11585.

AMA Style

Furdui B, Parfene G, Ghinea IO, Dinica RM, Bahrim G, Demeunynck M. Synthesis and in Vitro Antimicrobial Evaluation of New N-Heterocyclic Diquaternary Pyridinium Compounds. Molecules. 2014; 19(8):11572-11585.

Chicago/Turabian Style

Furdui, Bianca; Parfene, Georgiana; Ghinea, Ioana O.; Dinica, Rodica M.; Bahrim, Gabriela; Demeunynck, Martine. 2014. "Synthesis and in Vitro Antimicrobial Evaluation of New N-Heterocyclic Diquaternary Pyridinium Compounds." Molecules 19, no. 8: 11572-11585.


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