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Molecules 2014, 19(8), 11341-11349; doi:10.3390/molecules190811341

Two New Acylated Flavonol Glycosides from the Seeds of Lepidium sativum

Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
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Received: 16 May 2014 / Revised: 21 July 2014 / Accepted: 22 July 2014 / Published: 31 July 2014
(This article belongs to the Section Natural Products)
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Abstract

Two new acylated flavonol glycosides named kaempferol-3-O-(2-O-sinapoyl)-β-D-galactopyranosyl-(1→2)-β-D-glucopyranoside-7-O-α-L-rhamnopyranoside (1) and quercetin-3-O-(6-O-benzoyl)-β-D-glucopyranosyl-(1→3)-β-D-galactopyranoside-7-O-α-L-rhamnopyranoside (2), were isolated together with six known compounds from the seeds of L. sativum. Their structures were elucidated on the basis of spectroscopic analysis and chemical methods. In vitro 1 and 2 inhibited nitric oxide production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, with IC50 values of 25.36 and 25.08 µM, respectively. View Full-Text
Keywords: Lepidium sativum; flavonol glycoside; anti-inflammatory activity Lepidium sativum; flavonol glycoside; anti-inflammatory activity
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Fan, Q.-L.; Zhu, Y.-D.; Huang, W.-H.; Qi, Y.; Guo, B.-L. Two New Acylated Flavonol Glycosides from the Seeds of Lepidium sativum. Molecules 2014, 19, 11341-11349.

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