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Molecules 2014, 19(8), 11333-11340; doi:10.3390/molecules190811333

Synthesis and Antifungal Activity of Novel Triazole Compounds Containing Piperazine Moiety

1
Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, 325Guohe Road, Shanghai 200433, China
2
Shanghai Key Laboratory of Molecular Medical Mycology, Department of Dermatology, Shanghai Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China
3
Department of Pharmacy, No. 422 Hospital of PLA, 40 Haibin No. 3 Road, Zhanjiang 524000, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 7 June 2014 / Revised: 18 July 2014 / Accepted: 21 July 2014 / Published: 31 July 2014
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [806 KB, uploaded 31 July 2014]   |  

Abstract

Design and synthesis of triazole library antifungal agents having piperazine side chains, analogues to fluconazole were documented. The synthesis highlighted utilization of the click chemistry on the basis of the active site of the cytochrome P450 14α-demethylase (CYP51). Their structures were characterized by 1H-NMR, 13C-NMR, MS and IR. The influences of piperazine moiety on in vitro antifungal activities of all the target compounds were evaluated against eight human pathogenic fungi. View Full-Text
Keywords: antifungal; triazole; synthesis; piperazine antifungal; triazole; synthesis; piperazine
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Wang, Y.; Xu, K.; Bai, G.; Huang, L.; Wu, Q.; Pan, W.; Yu, S. Synthesis and Antifungal Activity of Novel Triazole Compounds Containing Piperazine Moiety. Molecules 2014, 19, 11333-11340.

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