Molecules 2014, 19(5), 6439-6449; doi:10.3390/molecules19056439
Article

Palladium-Catalyzed Direct Addition of 2-Aminobenzonitriles to Sodium Arylsulfinates: Synthesis of o-Aminobenzophenones

1,2, 1email and 1,* email
Received: 3 May 2014; in revised form: 15 May 2014 / Accepted: 19 May 2014 / Published: 20 May 2014
(This article belongs to the Special Issue Palladium Catalysts)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The first example of the palladium-catalyzed synthesis of o-aminobenzophenones in moderate to excellent yields via a direct addition of sodium arylsulfinates to unprotected 2-aminobenzonitriles was reported. A plausible mechanism for the formation of o-aminobenzophenones involving desulfination and addition reactions was proposed. The utility of this transformation was demonstrated by its compatibility with a wide range of functional groups. Thus, the method represents a convenient and practical strategy for synthesis of o-aminobenzophenones.
Keywords: palladium; 2-aminobenzonitriles; arylsulfinates; o-aminobenzophenones
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MDPI and ACS Style

Chen, J.; Li, J.; Su, W. Palladium-Catalyzed Direct Addition of 2-Aminobenzonitriles to Sodium Arylsulfinates: Synthesis of o-Aminobenzophenones. Molecules 2014, 19, 6439-6449.

AMA Style

Chen J, Li J, Su W. Palladium-Catalyzed Direct Addition of 2-Aminobenzonitriles to Sodium Arylsulfinates: Synthesis of o-Aminobenzophenones. Molecules. 2014; 19(5):6439-6449.

Chicago/Turabian Style

Chen, Jiuxi; Li, Jianjun; Su, Weike. 2014. "Palladium-Catalyzed Direct Addition of 2-Aminobenzonitriles to Sodium Arylsulfinates: Synthesis of o-Aminobenzophenones." Molecules 19, no. 5: 6439-6449.

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