Next Article in Journal
Chlorine Isotope Effects from Isotope Ratio Mass Spectrometry Suggest Intramolecular C-Cl Bond Competition in Trichloroethene (TCE) Reductive Dehalogenation
Next Article in Special Issue
Palladium Catalyzed Heck Arylation of 2,3-Dihydrofuran—Effect of the Palladium Precursor
Previous Article in Journal
Antiprotozoal Activity of Achillea ptarmica (Asteraceae) and Its Main Alkamide Constituents
Previous Article in Special Issue
Repetitive Two-Step Method for o,o,p- and o,p-Oligophenylene Synthesis through Pd-Catalyzed Cross-Coupling of Hydroxyterphenylboronic Acid
Article Menu

Export Article

Open AccessArticle
Molecules 2014, 19(5), 6439-6449; doi:10.3390/molecules19056439

Palladium-Catalyzed Direct Addition of 2-Aminobenzonitriles to Sodium Arylsulfinates: Synthesis of o-Aminobenzophenones

Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China
College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou 325035, China
Author to whom correspondence should be addressed.
Received: 3 May 2014 / Revised: 15 May 2014 / Accepted: 19 May 2014 / Published: 20 May 2014
(This article belongs to the Special Issue Palladium Catalysts)
View Full-Text   |   Download PDF [318 KB, uploaded 18 June 2014]   |  


The first example of the palladium-catalyzed synthesis of o-aminobenzophenones in moderate to excellent yields via a direct addition of sodium arylsulfinates to unprotected 2-aminobenzonitriles was reported. A plausible mechanism for the formation of o-aminobenzophenones involving desulfination and addition reactions was proposed. The utility of this transformation was demonstrated by its compatibility with a wide range of functional groups. Thus, the method represents a convenient and practical strategy for synthesis of o-aminobenzophenones.
Keywords: palladium; 2-aminobenzonitriles; arylsulfinates; o-aminobenzophenones palladium; 2-aminobenzonitriles; arylsulfinates; o-aminobenzophenones

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Chen, J.; Li, J.; Su, W. Palladium-Catalyzed Direct Addition of 2-Aminobenzonitriles to Sodium Arylsulfinates: Synthesis of o-Aminobenzophenones. Molecules 2014, 19, 6439-6449.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top