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Molecules 2014, 19(6), 8402-8413; doi:10.3390/molecules19068402
Article

Palladium Catalyzed Heck Arylation of 2,3-Dihydrofuran—Effect of the Palladium Precursor

1, 1,*  and 2
Received: 26 May 2014 / Revised: 10 June 2014 / Accepted: 12 June 2014 / Published: 19 June 2014
(This article belongs to the Special Issue Palladium Catalysts)
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Abstract

Heck arylation of 2,3-dihydrofuran with iodobenzene was carried out in systems consisting of different palladium precursors (Pd2(dba)3, Pd(acac)2, PdCl2(cod), [PdCl(allyl)]2, PdCl2(PhCN)2, PdCl2(PPh3)2) and ionic liquids (CILs) with L-prolinate or L-lactate anions. All the tested CILs caused remarkable increases of the conversion values and in all of the reactions 2-phenyl-2,3-dihydrofuran (3) was obtained as the main product with a yield of up to 59.2%. The highest conversions of iodobenzene were achieved for the [PdCl(allyl)]2 precursor. Formation of Pd(0) nanoparticles, representing the resting state of the catalyst, was evidenced by TEM.
Keywords: palladium; Heck coupling; ionic liquids; nanoparticles palladium; Heck coupling; ionic liquids; nanoparticles
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Morel, A.; Trzeciak, A.M.; Pernak, J. Palladium Catalyzed Heck Arylation of 2,3-Dihydrofuran—Effect of the Palladium Precursor. Molecules 2014, 19, 8402-8413.

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